Verani P, Mariani G, Mannucci P M, De Rossi G, Nicoletti L, Titti F, Falcione E, Pasqualetti D, Ammassari M, Gringeri A
J Med Virol. 1986 Jun;19(2):143-9. doi: 10.1002/jmv.1890190206.
The prevalence of HTLV-III/LAV antibodies was evaluated in 222 Italian asymptomatic hemophiliacs treated exclusively with commercial factor concentrates made with American plasma. An increase of HTLV-III/LAV seropositivity from 1983 to 1985 was evident. This was independent of the type of hemophilia (A or B) but directly correlated to the amount of concentrate administered in the previous year. Immunological data (T4 and T8 lymphocyte subsets) were evaluated in relation to seropositivity to HTLV-III/LAV. The presence of antibodies was found to be significantly associated with a low T4/T8 ratio and to a reduced T4 subpopulation, whereas increased levels of T8 lymphocytes correlated weakly with seropositivity. Data from 47 hemophiliacs tested both in 1984 and 1985 showed that 100% of those negative in 1984 and highly transfused in the previous year seroconverted up to 1985, whereas 33% of those not highly transfused did so.
对222名仅接受用美国血浆制成的商业浓缩因子治疗的意大利无症状血友病患者进行了HTLV-III/LAV抗体流行率评估。1983年至1985年期间，HTLV-III/LAV血清阳性率明显上升。这与血友病类型（A或B）无关，但与上一年输注的浓缩因子量直接相关。针对HTLV-III/LAV血清阳性情况评估了免疫数据（T4和T8淋巴细胞亚群）。发现抗体的存在与低T4/T8比值以及T4亚群减少显著相关，而T8淋巴细胞水平升高与血清阳性的相关性较弱。1984年和1985年对47名血友病患者进行检测的数据显示，1984年呈阴性且上一年大量输血的患者中，到1985年100%发生了血清转化，而未大量输血的患者中这一比例为33%。
