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1
Abnormalities of in vitro immunoglobulin production in apparently healthy haemophiliacs: relationship with alterations of T cell subsets and with HTLV-III seropositivity.表面健康的血友病患者体外免疫球蛋白产生异常：与T细胞亚群改变及人嗜T淋巴细胞病毒III型血清阳性的关系
Clin Exp Immunol. 1986 Feb;63(2):354-8.
2
Deficiency of the autologous mixed lymphocyte reaction in patients with classic hemophilia treated with commercial factor VIII concentrate. Correlation with T cell subset distribution, antibodies to lymphadenopathy-associated or human T lymphotropic virus, and analysis of the cellular basis of the deficiency.接受商业性凝血因子 VIII 浓缩物治疗的经典血友病患者自体混合淋巴细胞反应缺陷。与 T 细胞亚群分布、淋巴结病相关抗体或人类嗜 T 淋巴细胞病毒抗体的相关性，以及该缺陷细胞基础的分析。
J Clin Invest. 1985 Jun;75(6):1828-34. doi: 10.1172/JCI111896.
3
HTLV-III status and abnormalities in T lymphocyte distribution in children with hemophilia A.甲型血友病患儿的人类嗜T淋巴细胞病毒III型（HTLV-III）感染状况及T淋巴细胞分布异常
Diagn Immunol. 1986;4(1):37-42.
4
Abnormal B cell function in haemophiliacs and their relationship with factor concentrates administration.血友病患者的B细胞功能异常及其与凝血因子浓缩剂给药的关系。
Clin Exp Immunol. 1985 Feb;59(2):491-8.
5
One year follow-up study of T-cell subsets and incidence of seropositivity for HTLV-I and HTLV-III antibodies in patients treated "on demand" or sporadically with clotting concentrates.
Thromb Haemost. 1985 Oct 30;54(3):665-8.
6
HTLV-III infection in homosexuals and hemophiliacs in Sweden.瑞典同性恋者和血友病患者中的人类嗜T淋巴细胞病毒III型感染
Cancer Res. 1985 Sep;45(9 Suppl):4609s-4611s.
7
[Immunological status of hemophiliacs: study of blood T-lymphocyte populations, serum immunoglobulins, and the prevalence of anti-LAV antibodies].
Pathol Biol (Paris). 1985 Dec;33(10):951-6.
8
HTLV-III seropositivity in symptom-free Italian haemophiliacs. Correlation with consumption of commercial concentrate and abnormalities of T and B lymphocytes.
Scand J Haematol. 1986 Feb;36(2):198-202. doi: 10.1111/j.1600-0609.1986.tb00828.x.
9
HTLV-III antibody and T-cell subset ratios in haemophiliacs and their spouses.
Br J Haematol. 1986 Jun;63(2):347-52. doi: 10.1111/j.1365-2141.1986.tb05558.x.
10
Prevalence of HTLV-III/LAV antibodies in Italian asymptomatic hemophiliacs given commercial concentrates of factors VIII and IX.意大利无症状血友病患者中HTLV-III/LAV抗体在接受商业性VIII因子和IX因子浓缩剂治疗情况下的流行情况。
J Med Virol. 1986 Jun;19(2):143-9. doi: 10.1002/jmv.1890190206.

引用本文的文献

1
Lymphocyte autoantibodies and alloantibodies in HIV-positive haemophilia patients.HIV 阳性血友病患者中的淋巴细胞自身抗体和同种抗体。
Clin Exp Immunol. 1989 Feb;75(2):178-83.
2
Randomised controlled trial of interferon alfa 2A (rbe) (Roferon-A) for the treatment of chronic hepatitis B virus (HBV) infection: factors that influence response.干扰素α 2A（rbe）（罗扰素-A）治疗慢性乙型肝炎病毒（HBV）感染的随机对照试验：影响疗效的因素
Gut. 1989 Aug;30(8):1116-22. doi: 10.1136/gut.30.8.1116.
3
Increased interleukin 6 concentrations in the absence and presence of HIV-1 infection in haemophilia.血友病患者在感染和未感染HIV-1情况下白细胞介素6浓度均升高。
J Clin Pathol. 1992 Sep;45(9):766-9. doi: 10.1136/jcp.45.9.766.

本文引用的文献

1
B-cell immunodeficiency in acquired immune deficiency syndrome.获得性免疫缺陷综合征中的B细胞免疫缺陷
JAMA. 1984 Mar 16;251(11):1447-9.
2
Abnormalities of in vitro immunoglobulin synthesis by peripheral blood lymphocytes from untreated patients with Hodgkin's disease.未经治疗的霍奇金病患者外周血淋巴细胞体外免疫球蛋白合成异常。
J Clin Invest. 1983 May;71(5):1375-82. doi: 10.1172/jci110890.
3
Defective B-lymphocyte function in homosexual men in relation to the acquired immunodeficiency syndrome.同性恋男性中与获得性免疫缺陷综合征相关的B淋巴细胞功能缺陷
Ann Intern Med. 1984 Dec;101(6):757-63. doi: 10.7326/0003-4819-101-6-757.
4
The acquired immunodeficiency syndrome and Mycobacterium avium-intracellulare bacteremia in a patient with hemophilia.一名血友病患者的获得性免疫缺陷综合征与鸟分枝杆菌-胞内分枝杆菌菌血症
Ann Intern Med. 1983 Mar;98(3):290-3. doi: 10.7326/0003-4819-98-3-290.
5
Acquired immunodeficiency syndrome with Pneumocystis carinii pneumonia and Mycobacterium avium-intracellulare infection in a previously healthy patient with classic hemophilia. Clinical, immunologic, and virologic findings.一名既往健康的典型血友病患者发生获得性免疫缺陷综合征，合并卡氏肺孢子虫肺炎和鸟分枝杆菌复合群感染。临床、免疫学及病毒学检查结果
Ann Intern Med. 1983 Mar;98(3):287-90. doi: 10.7326/0003-4819-98-3-287.
6
Abnormalities of lymphocyte subsets are correlated with concentrate consumption in asymptomatic Italian hemophiliacs treated with concentrates made from American plasma.在接受美国血浆制成的浓缩物治疗的无症状意大利血友病患者中，淋巴细胞亚群异常与浓缩物消耗量相关。
Am J Hematol. 1984 Aug;17(2):167-76. doi: 10.1002/ajh.2830170208.
7
Displacement of T lymphocytes with the 'Helper/Inducer' phenotype from peripheral blood to lymphoid organs in untreated patients with Hodgkin's disease.在未经治疗的霍奇金病患者中，具有“辅助/诱导”表型的T淋巴细胞从外周血向淋巴器官的移位。
Scand J Haematol. 1983 Oct;31(4):305-14. doi: 10.1111/j.1600-0609.1983.tb00658.x.
8
Abnormalities of B-cell activation and immunoregulation in patients with the acquired immunodeficiency syndrome.获得性免疫缺陷综合征患者B细胞激活及免疫调节异常
N Engl J Med. 1983 Aug 25;309(8):453-8. doi: 10.1056/NEJM198308253090803.
9
Detection, isolation, and continuous production of cytopathic retroviruses (HTLV-III) from patients with AIDS and pre-AIDS.从艾滋病患者和艾滋病前期患者中检测、分离并持续生产细胞病变逆转录病毒（HTLV-III）。
Science. 1984 May 4;224(4648):497-500. doi: 10.1126/science.6200935.
10
Isolation of a T-lymphotropic retrovirus from a patient at risk for acquired immune deficiency syndrome (AIDS).从一名有获得性免疫缺陷综合征（艾滋病）风险的患者体内分离出一种嗜T淋巴细胞逆转录病毒。
Science. 1983 May 20;220(4599):868-71. doi: 10.1126/science.6189183.

表面健康的血友病患者体外免疫球蛋白产生异常：与T细胞亚群改变及人嗜T淋巴细胞病毒III型血清阳性的关系

Abnormalities of in vitro immunoglobulin production in apparently healthy haemophiliacs: relationship with alterations of T cell subsets and with HTLV-III seropositivity.

作者信息

Biagiotti R, Giudizi M G, Almerigogna F, Mazzetti M, Alessi A, Del Prete G F, Rafanelli D, Fiorilli M, Morfini M, Romagnani S

出版信息

Clin Exp Immunol. 1986 Feb;63(2):354-8.

PMID:3009063
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1577369/
Abstract

The pokeweed mitogen (PWM)-induced immunoglobulin (Ig) production by cultures of peripheral blood mononuclear cells (PBMC) was reduced in healthy haemophiliacs treated with commercial factor VIII (or IX) concentrate, whereas the spontaneous IgG synthesis in vitro was enhanced. PWM-induced Ig production was lower in those who had received greater amounts of concentrate, in those with inverted T4/T8 lymphocyte ratios and in those with antibody to HTLV-III. The spontaneous IgG production in vitro was higher in haemophiliacs who had received larger amounts of concentrate, in those with inverted T4/T8 ratio and in those with antibody anti-HTLV-III. However, some patients with normal T4/T8 ratio and some with HTLV-III antibody also had raised spontaneous IgG production.

摘要

在用商业性因子VIII（或IX）浓缩物治疗的健康血友病患者中，外周血单核细胞（PBMC）培养物经商陆有丝分裂原（PWM）诱导产生免疫球蛋白（Ig）的能力降低，而体外自发IgG合成增强。接受浓缩物剂量较大的患者、T4/T8淋巴细胞比例倒置的患者以及患有抗HTLV-III抗体的患者，其PWM诱导的Ig产生较低。接受浓缩物剂量较大的血友病患者、T4/T8比例倒置的患者以及患有抗HTLV-III抗体的患者，其体外自发IgG产生较高。然而，一些T4/T8比例正常的患者和一些患有HTLV-III抗体的患者也有自发IgG产生增加的情况。