Cirillo M, Strazzullo P, Galletti F, Siani A, Nunziata V
J Clin Hypertens. 1985 Mar;1(1):30-4.
Altered regulation of serum calcium level was proposed to be associated with arterial hypertension and to be dependent on a renal calcium leak or an altered calcium binding to plasma proteins and cell membrane described in human and experimental hypertension. The aim of this study was to analyze the regulation of serum total and ionized calcium levels during an intravenous calcium infusion (0.25 mmol calcium/kg body weight/hr for 2 hours) in a group of untreated essential hypertensives and a comparable normotensive group. Basal serum calcium concentrations did not differ between the two groups, whereas parathyroid activity and urinary calcium were significantly increased in hypertensive subjects. During the calcium load, serum calcium rose almost linearly in all subjects but with a reduced slope in the hypertensive group, which showed serum total and ionized calcium levels significantly lower than those of the controls at the end of the infusion. Our data indicate that hypertensive patients have an altered regulation of serum calcium concentrations, probably due to a different body distribution of calcium, rather than to an altered calcium binding to plasma proteins.
血清钙水平调节异常被认为与动脉高血压有关，且依赖于肾钙泄漏或钙与血浆蛋白及细胞膜结合的改变，这在人类和实验性高血压中均有描述。本研究的目的是分析一组未经治疗的原发性高血压患者和一组血压正常的对照人群在静脉输注钙（0.25 mmol钙/千克体重/小时，持续2小时）期间血清总钙和离子钙水平的调节情况。两组的基础血清钙浓度无差异，而高血压患者的甲状旁腺活性和尿钙显著升高。在钙负荷期间，所有受试者的血清钙几乎呈线性上升，但高血压组的斜率降低，输注结束时其血清总钙和离子钙水平显著低于对照组。我们的数据表明，高血压患者血清钙浓度的调节发生改变，可能是由于钙在体内的分布不同，而非钙与血浆蛋白的结合改变。
