Ricciardelli D, Piccini L, Forgeschi M, Sanna A, Bandinelli R, Pala A M
Istituto di Clinica Medica Generale e Terapia Medica III, U.S.L. 10/D, Firenze.
Minerva Med. 1990 Oct;81(10):683-6.
Serum concentrations of ionized calcium have been measured in a group of 38 patients with essential hypertension (26 women and 12 men with mean age 61 +/- 12 years) and in a group of 19 normotensives (14 women and 5 men with mean age 70 +/- 12 years). Serum Ca++ levels were significantly lower in hypertensives than in normotensives (4.16 +/- 0.43 mg/dl and 4.46 +/- 0.38 mg/dl respectively, with p less than 0.05). The lower serum concentrations found in hypertensives may be due ions in arterial smooth muscle cells may cause an increase of vascular tone and peripheral resistances. Our results support, in agreement with other Authors, the possible role of ionized calcium in the pathogenesis of essential hypertension.
对一组38例原发性高血压患者（26名女性和12名男性，平均年龄61±12岁）和一组19名血压正常者（14名女性和5名男性，平均年龄70±12岁）测量了血清离子钙浓度。高血压患者的血清Ca++水平显著低于血压正常者（分别为4.16±0.43mg/dl和4.46±0.38mg/dl，p<0.05）。高血压患者中发现的较低血清浓度可能是由于动脉平滑肌细胞中的离子可能导致血管张力和外周阻力增加。与其他作者一致，我们的结果支持离子钙在原发性高血压发病机制中可能发挥的作用。
