Eliahou H E, Serban I, Gavendo S, Kapuler S, Farfel Z, Iaina A
J Clin Hypertens. 1985 Jun;1(2):132-7.
Beta adrenergic receptor binding sites were determined and characterized by specific binding of (+/-)[125I] iodocyanopindolol to membranes obtained from circulating polymorphonuclear leukocytes. No difference was found in the number of receptor sites and in their dissociation constants (Kd) between patients with untreated essential hypertension (EH), EH treated with drugs other than beta blockers, and in normotensive controls. The group with EH receiving treatment with beta blockers had a significantly higher receptor density and Kd as compared with all the other groups (p less than 0.05). It is concluded that the beta-adrenergic system of patients with essential hypertension at the receptor level is not different from normotensive subjects and responds to beta blockers by up-regulation.
通过（±）[125I]碘氰吲哚洛尔与循环多形核白细胞膜的特异性结合来测定和表征β肾上腺素能受体结合位点。在未经治疗的原发性高血压（EH）患者、接受非β受体阻滞剂药物治疗的EH患者和血压正常的对照组之间，未发现受体位点数量及其解离常数（Kd）存在差异。与所有其他组相比，接受β受体阻滞剂治疗的EH组具有显著更高的受体密度和Kd（p<0.05）。得出的结论是，原发性高血压患者在受体水平的β肾上腺素能系统与血压正常的受试者没有差异，并且会通过上调对β受体阻滞剂产生反应。
