Corradi L, Negri F, Parini A, Partesana N, Finardi G
Boll Soc Ital Biol Sper. 1981 Sep 15;57(17):1766-70.
Number and affinity of beta-adrenoceptors in human polymorphonucleates (PMN's) have been studied in patients with essential hypertension (n = 12) and in normal subjects of the same range of age and sex (n = 16). (-)Diidroalprenolol-H3 has been utilized as ligand. Membranes preparation was performed according to Galant (5). Number of beta-adrenoceptor is significantly decreased compared with controls (p less than 0.05), both with saturation curves and Scatchard analysis. Affinity of beta-adrenoceptors toward (-)diidroalprenolol-H3 is lightly increased but not significantly. These data could be explained on the basis of the desensitization occurring in hypertensive subjects by altered plasma catecholamines level, as in experimental in vitro systems.
对12例原发性高血压患者和16例年龄及性别范围相同的正常受试者的人多形核白细胞（PMN）中的β-肾上腺素能受体数量和亲和力进行了研究。使用（-）二氢心得舒-H3作为配体。根据加兰特（5）的方法制备膜。无论是饱和曲线还是斯卡查德分析，与对照组相比，β-肾上腺素能受体数量均显著减少（p<0.05）。β-肾上腺素能受体对（-）二氢心得舒-H3的亲和力略有增加，但不显著。这些数据可以根据高血压患者因血浆儿茶酚胺水平改变而发生的脱敏作用来解释，就像在体外实验系统中一样。
