HIV感染中的性别差异：神秘主义与大男子主义
Sex Differences in HIV Infection: Mystique Versus Machismo.
作者信息
Scully Eileen P
机构信息
Department of Medicine, Division of Infectious Diseases, Johns Hopkins University School of Medicine.
出版信息
Pathog Immun. 2018;3(1):82-113. doi: 10.20411/pai.v3i1.238. Epub 2018 Jul 13.
Abstract
Biological sex is a determinant of both susceptibility to and pathogenesis of multiple infections, including HIV. These differences have effects on the spectrum of HIV disease from acquisition to eradication, with diverse mechanisms including distinct chromosomal complements, variation in microbiota composition, hormonal effects on transcriptional profiles, and expression of different immunoregulatory elements. With a comparative biology approach, these sex differences can be used to highlight protective and detrimental immune activation pathways, to identify strategies for effective prevention, treatment, and curative interventions.
摘要
生物性别是包括HIV在内的多种感染易感性和发病机制的一个决定因素。这些差异对从感染到根除的HIV疾病谱有影响，其机制多种多样，包括不同的染色体组成、微生物群组成的变化、激素对转录谱的影响以及不同免疫调节元件的表达。通过比较生物学方法，这些性别差异可用于突出保护性和有害性免疫激活途径，以确定有效的预防、治疗和治愈性干预策略。
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