Department of Dermatology and Allergy, University Hospital, LMU Munich, Frauenlobstr. 9-11, 80337, Munich, Germany.
Department of Dermatology, Heidelberg University Hospital, University of Heidelberg, Heidelberg, Germany.
Med Oncol. 2018 Aug 23;35(10):135. doi: 10.1007/s12032-018-1196-2.
Sarcomas are a heterogeneous group of mesenchymal tumors which can affect bone and soft tissue. Leiomyosarcoma (LMS) is a rare subtype localized to the skin or subcutaneous tissue. Due to the heterogeneity of sarcomas, reviews and guidelines with an in-depth focus specifically on primary LMS of the skin are sparse. This article is intended to provide an up to date and systematic overview on diagnosis, treatment, and surveillance of this rare entity to provide a framework for decision making and management for dermato-oncologists. We discuss novel treatment options for advanced disease such as targeted therapy with kinase inhibitors and immune checkpoint blockade which may improve the prognosis even in advanced stages of LMS.
肉瘤是一组异质性的间叶肿瘤，可以影响骨骼和软组织。平滑肌肉瘤（LMS）是一种罕见的亚型，局限于皮肤或皮下组织。由于肉瘤的异质性，专门针对皮肤原发性 LMS 的综述和指南很少。本文旨在提供对该罕见实体的最新和系统的诊断、治疗和监测概述，为皮肤科肿瘤学家提供决策和管理框架。我们讨论了晚期疾病的新的治疗选择，如激酶抑制剂的靶向治疗和免疫检查点阻断，这甚至可能改善 LMS 晚期的预后。
