Saratov State University, Research-Educational Institute of Optics and Biophotonics, Saratov, Russia.
Tomsk State University, Interdisciplinary Laboratory of Biophotonics, Tomsk, Russia.
J Biomed Opt. 2018 Aug;23(9):1-31. doi: 10.1117/1.JBO.23.9.091416.
Nowadays, dynamically developing optical (photonic) technologies play an ever-increasing role in medicine. Their adequate and effective implementation in diagnostics, surgery, and therapy needs reliable data on optical properties of human tissues, including skin. This paper presents an overview of recent results on the measurements and control of tissue optical properties. The issues reported comprise a brief review of optical properties of biological tissues and efficacy of optical clearing (OC) method in application to monitoring of diabetic complications and visualization of blood vessels and microcirculation using a number of optical imaging technologies, including spectroscopic, optical coherence tomography, and polarization- and speckle-based ones. Molecular modeling of immersion OC of skin and specific technique of OC of adipose tissue by its heating and photodynamic treatment are also discussed.
如今，快速发展的光学（光子）技术在医学领域发挥着越来越重要的作用。为了在诊断、手术和治疗中充分有效地应用这些技术，我们需要有关人体组织（包括皮肤）的光学特性的可靠数据。本文概述了近年来在组织光学特性的测量和控制方面的研究成果。本文报道的问题包括简要回顾生物组织的光学特性和光学透明化（OC）方法的效果，该方法应用于监测糖尿病并发症以及使用多种光学成像技术（包括光谱学、光学相干断层扫描和基于偏振和散斑的技术）来可视化血管和微循环。本文还讨论了皮肤浸液 OC 的分子建模和通过加热和光动力疗法对脂肪组织进行 OC 的特定技术。
