a Department of Biomedical Laboratory Science , Namseoul University , Cheonan-si , Chungcheongnam-do , South Korea.
b Department of Biomedical Laboratory Science , Dongnam Health University , Suwon-si , Gyeonggi-do , South Korea.
Clin Exp Hypertens. 2019;41(6):499-504. doi: 10.1080/10641963.2018.1510944. Epub 2018 Aug 24.
Hyperuricemia is associated with cardiovascular disease, but the relationship between uric acid (UA) and pulse pressure (PP) is unclear. Therefore, the present study assesses the relationship between UA and PP among Korean adults. Data from 6,310 subjects (2,800 men and 3,510 women) in the seventh Korean National Health and Nutrition Examination Survey (2016) were analyzed. After adjusting for related variables, the odds ratios (ORs) of hyperuricemia (UA ≥ 7.0 mg/dL in men or ≥ 6.0 mg/dL in women) in the high PP group (PP > 65.0 mmHg) in overall populations (OR, 1.563; 95% confidence interval [CI], 1.144-2.136) and women (OR, 1.631; 95% CI, 1.046-2.544) were significantly higher than those in normal PP, but not in men (OR, 1.309; 95% CI, 0.840-2.040). In conclusion, uric acid was positively associated with pulse pressure in women, but not in men.
高尿酸血症与心血管疾病有关，但尿酸（UA）与脉压（PP）之间的关系尚不清楚。因此，本研究评估了韩国成年人中 UA 与 PP 之间的关系。对 2016 年第七次韩国国家健康和营养检查调查（KNHANES Ⅶ）中 6310 名受试者（男性 2800 名，女性 3510 名）的数据进行了分析。在调整了相关变量后，在总体人群（OR，1.563；95%置信区间[CI]，1.144-2.136）和女性（OR，1.631；95%CI，1.046-2.544）中，高 PP 组（PP >65.0mmHg）的高尿酸血症（UA≥7.0mg/dL 男性或≥6.0mg/dL 女性）的比值比（OR）明显高于正常 PP 组，但男性则不然（OR，1.309；95%CI，0.840-2.040）。总之，尿酸与女性的脉压呈正相关，而与男性无关。
