Institute of Biomedical Sciences, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil.
Institute for Studies in Neuroscience and Complex Systems Studies, ENyS, CONICET, Buenos Aires, Argentina.
PLoS Biol. 2018 Aug 24;16(8):e2006592. doi: 10.1371/journal.pbio.2006592. eCollection 2018 Aug.
Zika virus (ZIKV) is a health burden due to the severe neurological abnormalities that arise after congenital infection. Although multiple experimental studies have linked ZIKV with neural birth defects, the scientific community has not been able to fully explain why Congenital Zika Syndrome (CZS) was only apparent after the virus entered the Americas and why these occurrences have an asymmetric geographic distribution. Here, we review the impact of ZIKV infection on human populations by exploring evolutionary changes in the virus' genome as well as examining the diverse genetic and environmental cofactors of the human hosts.
寨卡病毒（ZIKV）是一种健康负担，因为先天性感染后会出现严重的神经发育异常。尽管多项实验研究将 ZIKV 与神经出生缺陷联系起来，但科学界仍无法完全解释为什么先天性寨卡综合征（CZS）仅在病毒进入美洲后才出现，以及为什么这些事件的地理分布呈不对称性。在这里，我们通过研究病毒基因组的进化变化以及检查人类宿主的多种遗传和环境共同因素，来探讨寨卡病毒感染对人类的影响。
