Department of Chemistry, Payame Noor University, 19395-4697, Tehran, Iran.
Department of Chemistry, Payame Noor University, 19395-4697, Tehran, Iran; Department of Chemistry, Faculty of Science, University of Malaya, 50603, Kuala Lumpur, Malaysia; University Malaya Center for Ionic Liquids (UMCiL), University of Malaya, 50603, Kuala Lumpur, Malaysia.
J Pharm Biomed Anal. 2018 Nov 30;161:12-19. doi: 10.1016/j.jpba.2018.08.004. Epub 2018 Aug 7.
A highly efficient electrochemical sensor for the analysis of anticancer drug 5-fluorouracil (5-FU), is fabricated based on silver nanoparticles-polyaniline nanotube (AgNPs@PANINTs). AgNPs@PANINTs nanocomposite has been synthesized by a simple one-step method. Synthesized AgNPs@PANINTs nanocomposite was studied by Fourier transform infrared spectrometry, Scanning Electron Microscopy and Energy Dispersive X-ray. The fabricated PANINTs@AgNPs PGE was applied to the electrochemical sensing of 5-FU. Cyclic voltammetry and differential pulse voltammetry experiments illustrated high electro activity for the AgNPs@PANINTs nanocomposite. The study was explored using the Taguchi experimental design method. Electrochemical measurements using differential pulse voltammetry showed a wide linear relationship between 5-FU concentration and peak height within the range 1.0-300.0 μM with a low detection limit (0.06 μM). Also, the fabricated sensor showed excellent selectivity in the presence of two anticancer drugs and a number of other interfering compounds. The as-prepared sensor showed to be a promising device for a simple, rapid, and direct analysis of 5-FU.
一种基于银纳米粒子-聚苯胺纳米管（AgNPs@PANINTs）的高效电化学传感器被用于分析抗癌药物 5-氟尿嘧啶（5-FU）。AgNPs@PANINTs 纳米复合材料通过简单的一步法合成。通过傅里叶变换红外光谱、扫描电子显微镜和能谱对合成的 AgNPs@PANINTs 纳米复合材料进行了研究。所制备的 PANINTs@AgNPs PGE 被应用于 5-FU 的电化学传感。循环伏安法和差分脉冲伏安法实验表明，AgNPs@PANINTs 纳米复合材料具有高电活性。研究采用田口实验设计方法进行了探索。差分脉冲伏安法电化学测量显示，在 1.0-300.0 μM 的范围内，5-FU 浓度与峰高之间存在宽的线性关系，检测限低至 0.06 μM。此外，在存在两种抗癌药物和多种其他干扰化合物的情况下，所制备的传感器表现出优异的选择性。该制备的传感器有望成为一种简单、快速、直接分析 5-FU 的设备。
