Department of Neurology, Nanfang Hospital, Southern Medical University, Guangzhou, China.
Department of Neurology, The Affiliated Brain Hospital of Guangzhou Medical University, China.
Cytokine. 2018 Nov;111:140-145. doi: 10.1016/j.cyto.2018.08.017. Epub 2018 Aug 22.
Syndecan-1 (SDC-1) is a transmembrane member that has a profound influence on the resolution of inflammation. Soluble syndecan-1 (sSDC-1) levels have been shown to increase in many inflammatory diseases. However, it remains unknown whether sSDC-1 concentration is elevated in neuromyelitis optica (NMO) and multiple sclerosis (MS) patients. The aims of this pilot study were to investigate the relationship between sSDC-1 and disease severity in NMO and MS and whether sSDC-1 has potential as an effective marker for disease severity. We measured sSDC-1 concentrations by using an enzyme-linked immunosorbent assay (ELISA). NMO patients had significantly higher CSF sSDC-1 levels than MS patients or controls. We also found a positive correlation between the increased CSF sSDC-1 levels and increased severity in NMO disease, but not in MS. In NMO, CSF sSDC-1 concentrations were positively correlated with CSF interleukin (IL)-6, IL-8 and IL-17. Overall, we showed levels of CSF sSDC-1 were higher in NMO patients and had a positive relationship with disease severity of NMO but not with MS. CSF sSDC-1 may be an effective marker of NMO disease severity.
硫酸乙酰肝素蛋白聚糖 1（SDC-1）是一种跨膜成员，对炎症的消退有深远影响。已有研究表明，许多炎症性疾病中可溶性硫酸乙酰肝素蛋白聚糖 1（sSDC-1）水平升高。然而，视神经脊髓炎（NMO）和多发性硬化症（MS）患者中 sSDC-1 浓度是否升高仍不清楚。本研究旨在探讨 sSDC-1 与 NMO 和 MS 患者疾病严重程度的关系，以及 sSDC-1 是否可作为疾病严重程度的有效标志物。我们采用酶联免疫吸附试验（ELISA）检测 sSDC-1 浓度。与 MS 患者或对照组相比，NMO 患者脑脊液中 sSDC-1 水平显著升高。我们还发现，NMO 患者脑脊液中 sSDC-1 水平升高与疾病严重程度呈正相关，但在 MS 中无此相关性。在 NMO 中，脑脊液 sSDC-1 浓度与脑脊液白细胞介素（IL）-6、IL-8 和 IL-17 呈正相关。总的来说，我们发现 NMO 患者脑脊液 sSDC-1 水平升高，与 NMO 疾病严重程度呈正相关，与 MS 无关。脑脊液 sSDC-1 可能是 NMO 疾病严重程度的有效标志物。
