Department of Neurology, Tokyo Women's Medical University, School of Medicine, Tokyo, Japan.
J Neuroimmunol. 2013 Oct 15;263(1-2):148-51. doi: 10.1016/j.jneuroim.2013.07.005. Epub 2013 Jul 30.
Osteopontin (OPN) up-regulates pro-inflammatory cytokines from both T helper type 1 and T helper type 17 cell pathways. We measured plasma OPN levels in Japanese multiple sclerosis (MS) and neuromyelitis optica (NMO) patients to investigate its value as a potential biomarker of disease activity. In NMO patients, plasma OPN levels were significantly higher than those in healthy individuals, being equivalent to those in MS patients. In both NMO and MS patients, OPN levels were significantly higher during relapse compared with remission. There was also a significant positive correlation between Expanded Disability Status Scale of Kurzke scores and plasma OPN levels in both NMO and MS patients, and plasma OPN levels were significantly higher in patients with secondary progressive MS compared with those with relapsing-remitting MS. Diagnostic sensitivity and specificity of plasma OPN for MS and NMO during the relapse phase were 100% and 50%, respectively (cut-off point: 31.3ng/ml). Thus, elevated plasma OPN levels could be a potential biomarker for not only MS but also NMO. These are the first results to suggest that plasma OPN in NMO patients may be a useful marker, playing an important role in inflammation, disease activity, and disease progression, as well as MS.
骨桥蛋白 (OPN) 可上调 T 辅助 1 型和 T 辅助 17 型细胞通路中的促炎细胞因子。我们测量了日本多发性硬化症 (MS) 和视神经脊髓炎 (NMO) 患者的血浆 OPN 水平，以研究其作为疾病活动潜在生物标志物的价值。在 NMO 患者中，血浆 OPN 水平明显高于健康个体，与 MS 患者相当。在 NMO 和 MS 患者中，OPN 水平在复发时明显高于缓解期。NMO 和 MS 患者的扩展残疾状况量表 Kurzke 评分与血浆 OPN 水平之间也存在显著正相关，继发性进展型 MS 患者的血浆 OPN 水平明显高于复发缓解型 MS 患者。在复发期，血浆 OPN 对 MS 和 NMO 的诊断灵敏度和特异性均为 100%（临界值：31.3ng/ml）。因此，升高的血浆 OPN 水平可能不仅是 MS，而且是 NMO 的潜在生物标志物。这些结果首次表明，NMO 患者的血浆 OPN 可能是一种有用的标志物，在炎症、疾病活动和疾病进展中发挥重要作用，与 MS 也有关。
