Center for Integrated Protein Science Munich (CIPSM), Department of Chemistry, Technische Universität München, Lichtenbergstrasse 4, 85747 Garching, Germany.
Toxins (Basel). 2018 Aug 23;10(9):343. doi: 10.3390/toxins10090343.
Recent technological advances have seen increasing numbers of complex structures from diverse pore-forming toxins (PFT). The ClyA family of α-PFTs comprises a broad variety of assemblies including single-, two- and three-component toxin systems. With crystal structures available for soluble subunits of all major groups in this extended protein family, efforts now focus on obtaining molecular insights into physiological pore formation. This review provides an up-to-date discussion on common and divergent structural and functional traits that distinguish the various ClyA family PFTs. Open questions of this research topic are outlined and discussed.
近年来，越来越多的复杂结构来自于不同的孔形成毒素（PFT）。ClyA 家族的 α-PFT 包括各种各样的组装体，包括单、双和三组分毒素系统。由于该扩展蛋白家族的所有主要亚群的可溶性亚基的晶体结构都已可用，因此目前的工作重点是获得对生理孔形成的分子见解。本文综述了区分各种 ClyA 家族 PFT 的常见和不同的结构和功能特征的最新讨论。概述并讨论了该研究课题的悬而未决的问题。
