Melbourne IVF, 344 Victoria Parade, East Melbourne, Victoria 3002, Australia; The Royal Women's Hospital, Reproductive Services Unit, 20 Flemington Road, Parkville, Victoria 3052, Australia.
Melbourne IVF, 344 Victoria Parade, East Melbourne, Victoria 3002, Australia; The Royal Women's Hospital, Reproductive Services Unit, 20 Flemington Road, Parkville, Victoria 3052, Australia.
Best Pract Res Clin Obstet Gynaecol. 2019 Feb;55:67-78. doi: 10.1016/j.bpobgyn.2018.07.007. Epub 2018 Aug 1.
With improved survival rates from cancer, young people can expect to lead a normal life, including having their own children. However, cancer or other serious disease itself, and more often its treatment, often leads to a significant reduction in fertility or premature gonadal insufficiency. There is increasing acknowledgement for the importance of fertility preservation (FP) options to be discussed and offered to young people whose fertility is at risk, ideally before the gonadotoxic therapy begins. FP options currently include oocyte, embryo and ovarian tissue cryopreservation; ovarian protection during chemotherapy and semen, sperm and testicular tissue cryopreservation. A multidisciplinary team consisting of committed and enthusiastic doctors, scientists, nurses, counsellors, administrators and researchers is required to provide a holistic FP service with rapid response capacity for acute consultation and procedures and a robust system for long-term follow-up. This speciality is developing rapidly with exciting scientific advances that have relevance for the whole spectrum of reproductive medicine.
随着癌症生存率的提高，年轻人有望过上正常的生活，包括拥有自己的孩子。然而，癌症或其他严重疾病本身，更常见的是其治疗，往往会导致生育能力显著下降或过早的性腺功能不足。人们越来越认识到，对于那些生育能力受到威胁的年轻人，应该讨论并提供生育力保存（FP）的选择，理想情况下是在性腺毒性治疗开始之前。FP 的选择目前包括卵母细胞、胚胎和卵巢组织冷冻保存；化疗期间的卵巢保护以及精子、精液和睾丸组织冷冻保存。需要由有决心和热情的医生、科学家、护士、顾问、管理人员和研究人员组成的多学科团队，为急性咨询和手术提供全面的 FP 服务，并为长期随访建立强大的系统。随着与生殖医学整个领域相关的令人兴奋的科学进步，这一专业正在迅速发展。
