Balcar V J, Joó F, Kása P, Dammasch I E, Wolff J R
Neurosci Lett. 1986 May 23;66(3):269-74. doi: 10.1016/0304-3940(86)90030-3.
High affinity binding of [3H]gamma-aminobutyric acid (GABA) to membrane-containing homogenates prepared from rat cerebral cortex (neonatal or adult) or from adult rat superior cervical ganglion (SCG) was tested for sensitivity to baclofen, bicuculline and several other analogues of GABA. Since no major differences were found between the tissues free of GABAergic synapses (SCG and neonatal cortex) and GABAergic synapse-rich adult rat cortex, it is suggested that the presence of GABAergic synapses does not play a decisive role in the determination of pharmacological sensitivities of high-affinity GABA receptors.
测试了[³H]γ-氨基丁酸（GABA）与从大鼠大脑皮层（新生或成年）或成年大鼠颈上神经节（SCG）制备的含膜匀浆的高亲和力结合对巴氯芬、荷包牡丹碱和其他几种GABA类似物的敏感性。由于在不含GABA能突触的组织（SCG和新生皮层）与富含GABA能突触的成年大鼠皮层之间未发现重大差异，因此表明GABA能突触的存在在高亲和力GABA受体药理学敏感性的决定中不起决定性作用。
