用于结合研究的[3H]GABA的化学完整性。
Chemical integrity of [3H]GABA used in binding studies.
作者信息
Balcar V J
机构信息
Department of Anatomy, University of Sydney, N.S.W., Australia.
出版信息
Neurochem Res. 1989 Jul;14(7):593-5. doi: 10.1007/BF00964866.
PMID:2550828
Abstract
A method which is claimed to be able to determine the proportion of "true" GABA within radiolabeled GABA used in binding studies was tested using [3H]GABA. The method was found to be unsuitable for 3H-labeled GABA and, furthermore, both theoretical considerations and the present experimental data indicated that it could also produce misleading results with [14C]GABA.
摘要
一种据称能够确定在结合研究中使用的放射性标记γ-氨基丁酸（GABA）内“真实”GABA比例的方法，使用[³H]GABA进行了测试。结果发现该方法不适用于³H标记的GABA，此外，理论考量和当前实验数据均表明，该方法对[¹⁴C]GABA也可能产生误导性结果。
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