Hu Wei-Syun, Lin Cheng-Li
School of Medicine, College of Medicine, China Medical University, Taichung, Taiwan.
Division of Cardiovascular Medicine, Department of Medicine, China Medical University Hospital, Taichung, Taiwan.
Clin Cardiol. 2018 Oct;41(10):1374-1378. doi: 10.1002/clc.23063. Epub 2018 Oct 2.
The objective was to compare the rate of onset of atrial fibrillation (AF) in patients with benign prostatic hyperplasia (BPH) as compared with controls.
We performed a retrospective study on national health registry comparing the incidence of AF between a cohort of 15 670 BPH patients and a propensity-matched cohort of 15 670 control patients. Univariable and multivariable Cox proportional hazards models were performed to estimate the hazard ratios (HR) and 95% confidence intervals (CI) of incident AF associated with BPH. A subgroup analysis was performed to evaluate the risk of AF among BPH patients whether they received a BPH surgery or not as compared with those without BPH.
We found a 4.77 incidence rate per 1000 person-years in the BPH group, compared to 3.76 in the control group. After controlling for the confounders, a significant association between BPH and risk of incident AF was shown with an adjusted HR = 1.19, 95% CI = 1.11-1.28) and this association was attenuated once surgical intervention for BPH has been applied (adjusted HR = 0.86, 95% CI = 0.76-0.97).
This study supported the notion that BPH is associated with greater AF occurrence.
比较良性前列腺增生（BPH）患者与对照组中心房颤动（AF）的发作率。
我们对国家健康登记处进行了一项回顾性研究，比较了15670例BPH患者队列与15670例倾向匹配的对照患者队列中AF的发生率。采用单变量和多变量Cox比例风险模型来估计与BPH相关的新发AF的风险比（HR）和95%置信区间（CI）。进行亚组分析，以评估接受或未接受BPH手术的BPH患者与无BPH患者相比发生AF的风险。
我们发现BPH组每1000人年的发病率为4.77，而对照组为3.76。在控制混杂因素后，BPH与新发AF风险之间存在显著关联，调整后的HR = 1.19，95% CI = 1.11 - 1.28），并且一旦对BPH进行手术干预，这种关联就会减弱（调整后的HR = 0.86，95% CI = 0.76 - 0.97）。
本研究支持BPH与AF发生率较高相关的观点。
