Department of Medical Oncology, The First Hospital, China Medical University, Shenyang, China.
Department of Pathology, The First Hospital, China Medical University, Shenyang, China.
Thorac Cancer. 2018 Nov;9(11):1513-1518. doi: 10.1111/1759-7714.12848. Epub 2018 Aug 24.
Distant metastases of pulmonary adenocarcinoma are regularly observed in the bones, brain, adrenal gland, and liver, but rarely in the breast or cervix. In this report, we describe a novel case of concurrent cervix and breast metastases from lung adenocarcinoma, with ALK rearrangements that were strongly consistent between the primary and metastatic cancers. A 44-year-old Chinese woman with a chief complaint of abdominal discomfort was referred to our hospital. Based on diagnostic imaging, pathology, immunohistochemistry, and next-generation sequencing, the patient was diagnosed with lung adenocarcinoma with breast and cervical metastases, and ALK rearrangements were found in all three lesions. The patient was prescribed crizotinib as first-line treatment, which showed a steady reduction of the lung lesion. To our knowledge, this is the first report of concurrent breast and cervical metastases from lung adenocarcinoma. We conclude that physicians should consider that metastases may invade the breast and cervix uteri when making a diagnosis.
肺腺癌的远处转移通常发生在骨骼、大脑、肾上腺和肝脏，但很少发生在乳房或宫颈。在本报告中，我们描述了一例肺腺癌同时发生宫颈和乳房转移的新病例，其 ALK 重排与原发性和转移性癌症高度一致。一名 44 岁的中国女性因主诉腹部不适而被转至我院。根据诊断性影像学、病理学、免疫组织化学和下一代测序，患者被诊断为肺腺癌伴乳腺和宫颈转移，并且在所有三个病变中均发现了 ALK 重排。患者被开处克唑替尼作为一线治疗药物，其肺部病变稳定减少。据我们所知，这是首例肺腺癌同时发生乳房和宫颈转移的报告。我们的结论是，医生在诊断时应考虑转移可能会侵犯乳房和宫颈。
