Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Shimane, Japan.
Department of Gastroenterology and Hepatology, Shimane University School of Medicine, Shimane, Japan.
Clin Gastroenterol Hepatol. 2019 Jun;17(7):1405-1407. doi: 10.1016/j.cgh.2018.08.048. Epub 2018 Aug 23.
Eosinophilic esophagitis (EoE) is an allergic inflammatory disorder that is characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Its prevalence has been increasing rapidly in both Western and Asian countries. In Japan, most of the cases of esophageal eosinophilia (EE) are found in an upper endoscopy examination for gastric cancer screening performed during a comprehensive health check-up. Indeed, we frequently encounter patients with asymptomatic EE showing typical endoscopic findings, such as linear furrows, as well as histologic findings compatible with EoE. However, the current clinical guidelines for EoE diagnosis include symptoms related to esophageal dysfunction, thus patients without symptoms do not fulfill the diagnostic criteria. The clinical characteristics remain to be fully elucidated, thus we aimed to clarify clinical features of asymptomatic EE as compared with those of EoE.
嗜酸粒细胞性食管炎（EoE）是一种过敏性炎症性疾病，其临床特征为与食管功能障碍相关的症状，组织学特征为以嗜酸性粒细胞为主的炎症。在西方国家和亚洲国家，其发病率均迅速增加。在日本，大多数食管嗜酸性粒细胞增多症（EE）病例是在胃癌筛查的上消化道内镜检查中发现的。事实上，我们经常遇到无症状 EE 的患者，他们表现出典型的内镜下表现，如线性沟纹，以及与 EoE 相符的组织学表现。然而，目前 EoE 的临床诊断标准包括与食管功能障碍相关的症状，因此无症状的患者不符合诊断标准。其临床特征仍有待充分阐明，因此我们旨在阐明无症状 EE 与 EoE 的临床特征。
