School of Psychology, University of Leeds, Leeds, UK.
School of Psychology, University of Leeds, Leeds, UK.
Neurobiol Aging. 2018 Nov;71:149-155. doi: 10.1016/j.neurobiolaging.2018.07.004. Epub 2018 Jul 17.
The individual alpha peak frequency (IAPF) of the human electroencephalography (EEG) typically experiences slowing with increasing age. Despite this hallmark change, studies that investigate modulations of conventional EEG alpha power and connectivity by aging and age-related neuropathology neglect to account for intergroup differences in IAPF. To investigate the relationship of age-related IAPF slowing with EEG power and connectivity, we recorded eyes-closed resting-state EEG in 37 young adults and 32 older adults. We replicated the finding of a slowed IAPF in older adults. IAPF values were significantly correlated with the frequency of maximum global connectivity and the means of their distributions did not differ, suggesting that connectivity was highest at the IAPF. Older adults expressed reduced global EEG power and connectivity at the conventional upper alpha band (10-12 Hz) compared with young adults. By contrast, groups had equivalent power and connectivity at the IAPF. The results suggest that conventional spectral boundaries may be biased against older adults or any group with a slowed IAPF. We conclude that investigations of alpha activity in aging and age-related neuropathology should be adapted to the IAPF of the individual and that previous findings should be interpreted with caution. EEG in the dominant alpha range may be unsuitable for examining cortico-cortical connectivity due to its subcortical origins.
人类脑电图 (EEG) 的个体 alpha 峰频率 (IAPF) 通常随着年龄的增长而变慢。尽管这种标志性的变化存在，但研究衰老和与年龄相关的神经病理学对传统 EEG alpha 功率和连通性的调制时，忽略了 IAPF 的组间差异。为了研究与年龄相关的 IAPF 变慢与 EEG 功率和连通性的关系，我们在 37 名年轻成年人和 32 名老年人中记录了闭眼静息状态 EEG。我们复制了老年人 IAPF 变慢的发现。IAPF 值与最大全局连通性的频率显著相关，并且它们的分布平均值没有差异，这表明在 IAPF 处连通性最高。与年轻成年人相比，老年人在传统的上 alpha 频段（10-12 Hz）的全局 EEG 功率和连通性降低。相比之下，两个组在 IAPF 处具有等效的功率和连通性。结果表明，传统的频谱边界可能对老年人或任何 IAPF 较慢的群体存在偏见。我们得出结论，在衰老和与年龄相关的神经病理学中对 alpha 活动的研究应该适应个体的 IAPF，并且应该谨慎解释以前的发现。由于其皮质下起源，EEG 在优势 alpha 范围内可能不适合检查皮质间连通性。
