系统性红斑狼疮中抗DNA抗体、补体消耗与循环免疫复合物之间的关系。
Relationship between anti-DNA antibodies complement consumption and circulating immune complexes in systemic lupus erythematosus.
作者信息
Davis P, Cumming R H, Verrier-Jones J
出版信息
Clin Exp Immunol. 1977 May;28(2):226-32.
Abstract
Eighty-nine sera from nineteen patients with systemic lupus erythematosus (SLE) have been studied to determine the relationship between levels of DNA-binding activity, complement consumption and evidence of circulating immune complexes. There was a good correlation between the height of DNA binding, a rising C3i and a reciprocal fall in C3, C4 and CH50 levels. These latter measurements provided useful supplemental information when studied serially. There was a good correlation between the results of the various methods used for the detection of circulating immune complexes, and these were found in almost half the sera with DNA binding over 70%. It is concluded that serial studied of DNA binding, complement levels, and direct tests for immune complexes, may provide valuable information in the management of patients with SLE.
摘要
对19例系统性红斑狼疮（SLE）患者的89份血清进行了研究，以确定DNA结合活性水平、补体消耗与循环免疫复合物证据之间的关系。DNA结合水平升高、C3i升高以及C3、C4和CH50水平的相应下降之间存在良好的相关性。当进行连续研究时，这些后期测量提供了有用的补充信息。用于检测循环免疫复合物的各种方法的结果之间存在良好的相关性，并且在几乎一半DNA结合超过70%的血清中发现了循环免疫复合物。得出的结论是，对DNA结合、补体水平进行连续研究以及对免疫复合物进行直接检测，可能为SLE患者的管理提供有价值的信息。
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