Harkiss G D, Hazleman B L, Brown D L
J Clin Lab Immunol. 1979 Nov;2(4):275-83.
The relationship between immune complex, DNA binding and complement levels and disease activity was studied in twenty-seven patients with systemic lupus erythematosus. Detailed longitudinal studies revealed a good correlation between immune complex levels and disease activity. In addition, a good correlation was obtained, in general, between immune complex and DNA binding values, and an inverse correlation between these values and the haemolytic activity of C1, C2 and C4. CH50 and C3 measurements, on the other hand, were found to be less consistent at reflecting short term fluctuations in disease activity. Statistical analysis of IC, DNA binding and complement values revealed a higher incidence and mean value of immune complexex in active disease compared with inactive disease. These high levels of immune complexes were associated with elevated values of DNA binding and low values of CH50 and C3. The highest values of immune complexes were found in samples with concomitantly abnormal values of DNA binding, CH50 and C3. It is concluded that the measurement of immune complexes in SLE patients is a useful procedure, not only in aiding diagnosis, but also in monitoring disease activity and response to therapy. The results also indicate that serial studies of immune complexes, DNA binding and complement can be of value in the long term management of individual patients.
对27例系统性红斑狼疮患者的免疫复合物、DNA结合及补体水平与疾病活动度之间的关系进行了研究。详细的纵向研究显示免疫复合物水平与疾病活动度之间存在良好的相关性。此外，一般而言，免疫复合物与DNA结合值之间也存在良好的相关性，而这些值与C1、C2和C4的溶血活性之间呈负相关。另一方面，发现CH50和C3测量值在反映疾病活动度的短期波动方面不太一致。对免疫复合物、DNA结合和补体值的统计分析显示，与非活动性疾病相比，活动性疾病中免疫复合物的发生率和平均值更高。这些高水平的免疫复合物与DNA结合值升高以及CH50和C3值降低有关。在DNA结合、CH50和C3值同时异常的样本中发现免疫复合物的值最高。得出的结论是，对系统性红斑狼疮患者进行免疫复合物测量是一种有用的方法，不仅有助于诊断，还能监测疾病活动度及对治疗的反应。结果还表明，对免疫复合物、DNA结合和补体进行系列研究对个体患者的长期管理可能有价值。
