Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, 78712-1095, United States.
Waggoner Center for Alcohol and Addiction Research, The University of Texas at Austin, Austin, TX, 78712-1095, United States.
Alcohol. 2019 Feb;74:65-71. doi: 10.1016/j.alcohol.2018.05.004. Epub 2018 Aug 23.
Alcohol Use Disorder (AUD) is a multifarious psychiatric condition resulting from complex relationships between genetics, gene expression, neuroadaptations, and environmental influences. Understanding these complex relationships is essential to uncovering the mechanisms involved in the development and progression of AUD, with the ultimate goal of devising effective behavioral and therapeutic interventions. Technical advances in the fields of omics-based research and bioinformatics have yielded insights into gene interactions, biological networks, and cellular responses across humans and animal models. This review highlights several of the newly developed sequencing methodologies and resultant discoveries in neuroscience, as well as the importance of a multi-faceted and integrative approach for determining causal factors in AUD.
酒精使用障碍（AUD）是一种复杂的精神疾病，由遗传、基因表达、神经适应和环境影响之间的复杂关系导致。理解这些复杂关系对于揭示 AUD 发展和进展所涉及的机制至关重要，最终目标是设计有效的行为和治疗干预措施。基于组学的研究和生物信息学领域的技术进步，使人们深入了解了人类和动物模型中的基因相互作用、生物网络和细胞反应。这篇综述强调了神经科学中几种新开发的测序方法和相关发现，以及采用多方面和综合方法确定 AUD 因果因素的重要性。
