Byrne Tom
Department of Psychology, Massachusetts College of Liberal Arts, 375 Church Street, North Adams, MA, 01247, United States.
Neurosci Lett. 2018 Oct 15;685:102-108. doi: 10.1016/j.neulet.2018.08.030. Epub 2018 Aug 24.
The behavioral effects of ethanol in brown planarians were studied in four experiments. In the first two experiments, acute administrations of ethanol increased travel time in a dose-dependent fashion in individual planarians moving away from a light source. Orderly results were obtained using both within-subject and between-group designs. In a third experiment, ethanol dose was arranged by time rather than concentration. Ethanol increased travel time overall, but variability between subjects was considerable. In a final experiment, ethanol administration reduced motility and altered movement patterns in planarians in an open-field test. These experiments demonstrated that negative phototaxis by planarians may exhibit sufficient stability to allow for experimental determinations of dose-response curves utilizing both within-subject and between-subject designs.
在四项实验中研究了乙醇对棕色涡虫的行为影响。在前两项实验中，对单个远离光源移动的涡虫急性给予乙醇，乙醇的行为效应呈剂量依赖性增加移动时间。采用组内设计和组间设计均获得了有序的结果。在第三项实验中，乙醇剂量按时间而非浓度安排。乙醇总体上增加了移动时间，但个体间的变异性相当大。在最后一项实验中，在旷场试验中给予乙醇降低了涡虫的运动能力并改变了其运动模式。这些实验表明，涡虫的负趋光性可能表现出足够的稳定性，从而能够利用组内设计和组间设计对剂量反应曲线进行实验测定。
