Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA.
Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, PA, USA; Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA, USA.
Physiol Behav. 2019 Jul 1;206:181-184. doi: 10.1016/j.physbeh.2019.04.003. Epub 2019 Apr 2.
Avoidant behavior is a characteristic feature post-traumatic stress disorder (PTSD) and is modeled in mammals with predator odor. Light avoidance is a hallmark behavioral reaction in planarians. We hypothesized that planarians exposed to frog extract would display enhanced light avoidance that is prevented by fluoxetine. Enhanced light avoidance (i.e., less time spent in light compartment of a dish split into light and dark sides) after a 30-min frog extract exposure (0.0001-0.01%) manifested 15 min post-exposure, persisted for at least 24 h, and was counteracted by fluoxetine (10 μM). These results suggest conservation of an anxiety-like behavioral phenotype.
回避行为是创伤后应激障碍（PTSD）的一个特征，并且可以通过捕食者气味在哺乳动物中建模。光回避是水螅的一个标志性行为反应。我们假设，暴露于蛙提取物的水螅会表现出增强的光回避，而氟西汀可以阻止这种光回避。在暴露于 30 分钟的蛙提取物（0.0001-0.01%）后 15 分钟，水螅表现出增强的光回避（即在一个分为明暗两面的盘子的亮面停留的时间减少），这种反应至少持续 24 小时，并且可以被氟西汀（10 μM）逆转。这些结果表明，焦虑样行为表型具有保守性。
