Simúth J, Trnovský J, Jeloková J
Pharmazie. 1986 Feb;41(2):131-2.
Several UV-absorbing substances inhibiting the DNA-dependent RNA polymerases of Escherichia coli and Streptomyces aureofaciens, as well as the restriction endonuclease Eco RI have been isolated from the water-soluble extract of Propolis by two-dimensional paper chromatography. The inhibition of bacterial RNA-polymerases by the components of Propolis was probably due to the loss of their ability to bind to DNA. The general characteristic of the UV-absorbing component of Propolis with the most pronounced inhibitory effect upon transcription in vitro is described.
通过二维纸色谱法，从蜂胶的水溶性提取物中分离出了几种能抑制大肠杆菌和金色链霉菌的DNA依赖性RNA聚合酶以及限制性内切酶Eco RI的紫外线吸收物质。蜂胶成分对细菌RNA聚合酶的抑制作用可能是由于它们与DNA结合能力的丧失。本文描述了蜂胶中对体外转录具有最显著抑制作用的紫外线吸收成分的一般特征。
