41例原发性肝癌患者血清中的乙肝抗原和抗体。一项来自泰国的研究。

Hepatitis B antigens and antibodies in serum from 41 cases of primary carcinoma of the liver. A study from Thailand.

作者信息

Nørredam K, Chainuvati T, Aldershvile J, Nielsen J O, Viranuvatti V

出版信息

Scand J Gastroenterol. 1986 May;21(4):428-32. doi: 10.3109/00365528609015158.

Abstract

Thirty-seven patients with hepatocellular carcinoma (HCC), one with cholangiocellular carcinoma (CCC), two with mixed HCC and CCC, and one with an anaplastic primary carcinoma of the liver, all from Bangkok, Thailand, were examined for the presence of hepatitis B virus infection markers in their blood. Of the patients with HCC, 70.6% had macronodular cirrhosis. Their serum was positive for hepatitis B surface antigen (HBsAg) in 64.9%, for hepatitis B core antibody (anti-HBc) in 97.3%, and for hepatitis B e antibody (anti-HBe) in 56.8% of the cases. The serum was positive for hepatitis B surface antibody (anti-HBs) in 53.9% of the HBsAg-negative and positive for hepatitis B e antigen (HBeAg) in 16.7% of the HBsAg-positive patients. The results of the study support the hypothesis of an etiological association between hepatitis B virus infection and HCC in Thailand.

摘要

对来自泰国曼谷的37例肝细胞癌（HCC）患者、1例胆管细胞癌（CCC）患者、2例混合性HCC和CCC患者以及1例肝脏间变性原发性癌患者进行了血液中乙型肝炎病毒感染标志物检测。在HCC患者中，70.6%有大结节性肝硬化。他们的血清中，64.9%的病例乙型肝炎表面抗原（HBsAg）呈阳性，97.3%的病例乙型肝炎核心抗体（抗-HBc）呈阳性，56.8%的病例乙型肝炎e抗体（抗-HBe）呈阳性。在HBsAg阴性的病例中，53.9%的血清乙型肝炎表面抗体（抗-HBs）呈阳性；在HBsAg阳性的患者中，16.7%的血清乙型肝炎e抗原（HBeAg）呈阳性。该研究结果支持了泰国乙型肝炎病毒感染与HCC之间存在病因学关联的假说。