Thomas Christian, Lehrich Christoph, Gross Catharina C, Wiendl Heinz, Meuth Sven G, Melzer Nico
Clinic of Neurology with Institute of Translational Neurology, University of Münster, Münster, Germany.
Institute of Neuropathology, University of Münster, Münster, Germany.
Front Neurol. 2018 Aug 10;9:658. doi: 10.3389/fneur.2018.00658. eCollection 2018.
Limbic encephalitis is a potentially paraneoplastic type of encephalitis mainly involving the limbic system. Recently, diagnostic criteria comprising clinical presentation as well as imaging, laboratory and electrophysiological findings have been established. Here, we show that incipient primary central nervous system lymphoma can closely resemble limbic encephalitis including positive testing for anti-LGI1 antibodies illustrating the need for thorough interpretation of initial laboratory and radiologic findings and tight follow-up examinations.
边缘叶脑炎是一种潜在的副肿瘤性脑炎，主要累及边缘系统。最近，已经建立了包括临床表现以及影像学、实验室和电生理检查结果的诊断标准。在此，我们表明，早期原发性中枢神经系统淋巴瘤可能与边缘叶脑炎极为相似，包括抗LGI1抗体检测呈阳性，这说明需要对初始实验室和影像学检查结果进行全面解读，并进行密切的随访检查。
