Araki Takako, Liu Ning-Ai
Division of Diabetes, Endocrinology and Metabolism, Department of Medicine, University of Minnesota, Minneapolis, MN, United States.
Department of Medicine, Pituitary Center, Cedars-Sinai Medical Center, Los Angeles, CA, United States.
Front Endocrinol (Lausanne). 2018 Aug 10;9:444. doi: 10.3389/fendo.2018.00444. eCollection 2018.
Cell cycle proteins are critical to pituitary development, but their contribution to lineage-specific tumorigenesis has not been well-elucidated. Emerging evidence from human tumor analysis and transgenic mouse models indicates that G1/S-related cell cycle proteins, particularly cyclin E, p27, Rb, and E2F1, drive molecular mechanisms that underlie corticotroph-specific differentiation and development of Cushing disease. The aim of this review is to summarize the literature and discuss the complex role of cell cycle regulation in Cushing disease, with a focus on identifying potential targets for therapeutic intervention in patients with these tumors.
细胞周期蛋白对垂体发育至关重要，但其对谱系特异性肿瘤发生的作用尚未得到充分阐明。来自人类肿瘤分析和转基因小鼠模型的新证据表明，与G1/S相关的细胞周期蛋白，特别是细胞周期蛋白E、p27、视网膜母细胞瘤蛋白（Rb）和E2F1，驱动着促肾上腺皮质激素细胞特异性分化和库欣病发展的分子机制。这篇综述的目的是总结文献，并讨论细胞周期调控在库欣病中的复杂作用，重点是确定这些肿瘤患者治疗干预的潜在靶点。
