Huzhou Key Laboratory of Precise Prevention and Control of Major Chronic Diseases, School of Medicine, Huzhou University, 759 East 2nd Rd., Huzhou, 313000, China.
Botuvac Biotechnology Co., Ltd, Beijing, China.
Mol Biol Rep. 2024 Nov 17;51(1):1163. doi: 10.1007/s11033-024-10082-x.
Pin2/TRF1 interacting protein X1 (PinX1), a telomerase inhibitor, is located at human chromosome 8p23. This region is important for telomere length maintenance and chromosome stability, both of which are essential for regulating human ageing and associated diseases.
We investigated the research progress of PinX1 in human cancers. In cancers, the expression levels of PinX1 mRNA and protein vary according to cancer cell types, and PinX1 plays a critical role in the regulation of cancer development and progression. Additionally, a review of the literature indicates that PinX1 is involved in mitosis and affects the sensitivity of cancer cells to radiation-induced DNA damage. Therefore, PinX1 has therapeutic potential for cancer, and understanding the function of PinX1 in the regulation of cancers is crucial for improving treatment. In this review, we discuss the expression level of PinX1 in a variety of cancers and how it affects the implicated pathways. Additionally, we outline the function of PinX1 in cancer cells and provide a theoretical basis for PinX1-related cancer therapy.
PinX1 has promising prospects in future cancer therapeutics. This review may provide theoretical support for researchers in this field.
端粒酶抑制剂 Pin2/TRF1 相互作用蛋白 X1（PinX1）位于人类染色体 8p23 上。该区域对于端粒长度维持和染色体稳定性很重要，而这两者对于调节人类衰老和相关疾病都至关重要。
我们研究了 PinX1 在人类癌症中的研究进展。在癌症中，PinX1 mRNA 和蛋白的表达水平根据癌细胞类型而变化，PinX1 在调节癌症的发生和进展中起着关键作用。此外，文献综述表明，PinX1 参与有丝分裂，并影响癌细胞对辐射诱导的 DNA 损伤的敏感性。因此，PinX1 对癌症具有治疗潜力，了解 PinX1 在癌症调控中的功能对于改善治疗至关重要。在这篇综述中，我们讨论了 PinX1 在各种癌症中的表达水平以及它如何影响所涉及的途径。此外，我们概述了 PinX1 在癌细胞中的功能，并为 PinX1 相关的癌症治疗提供了理论基础。
PinX1 在未来的癌症治疗中有广阔的前景。这篇综述可能为该领域的研究人员提供理论支持。
