Ruban Aruchuna, Ashrafian Hutan, Teare Julian P
Department of Surgery and Cancer, Imperial College, London, UK.
Gastroenterol Res Pract. 2018 Jul 26;2018:7823182. doi: 10.1155/2018/7823182. eCollection 2018.
The rapid rise of obesity and type 2 diabetes poses a global threat to healthcare and is a major cause of mortality and morbidity. Bariatric surgery has revolutionised the treatment of both these conditions but is invasive and associated with an increased risk of complications. The EndoBarrier is a device placed endoscopically in the duodenum, which is designed to mimic the effects of gastric bypass surgery with the aim of inducing weight loss and improving glycaemic control. This review outlines the current clinical evidence of the device, its efficacy, potential mechanisms of action, and utility in clinical practice.
肥胖症和2型糖尿病的迅速增加对医疗保健构成了全球性威胁，并且是死亡率和发病率的主要原因。减肥手术彻底改变了这两种疾病的治疗方式，但具有侵入性且并发症风险增加。EndoBarrier是一种通过内镜放置在十二指肠的装置，旨在模拟胃旁路手术的效果，以达到减重和改善血糖控制的目的。本综述概述了该装置目前的临床证据、其疗效、潜在作用机制以及在临床实践中的应用。
