Chen Tzu-Chien, Tang Rui-Chian, Lin Jhih-Ni, Kuo Wei-Ting, Yang I-Hsuan, Liang Ya-Jyun, Lin Feng-Huei
Department of Biomedical Engineering, College of Medicine and College of Engineering National Taiwan University Taipei Taiwan.
Institute of Biomedical Engineering and Nanomedicine, National Health Research Institutes Zhunan, Miaoli County Taiwan.
Bioeng Transl Med. 2022 Aug 12;8(5):e10382. doi: 10.1002/btm2.10382. eCollection 2023 Sep.
Obesity is the most common health concern all over the world. However, till now, there is no promising way to manage obesity or body-weight control. The aim of the study is to develop an edible gel as a health supplement that temporarily attaches to the mucus of the intestines, forming an absorption barrier to block the nutrients. We modify the alginate with the thiol group as thiolated alginate (TA) that may stay on the mucosa layer for a much longer time to reduce nutrient absorption. In this study, the TA is synthesized successfully and proved a good mucosal adhesion to serve as a barrier for nutrient absorption both in vitro and in vivo. The results of in vivo imaging system (IVIS) show that the synthesized TA can be exiled from the gastrointestinal tract within 24 h. The animal study shows that the TA by daily oral administration can effectively reduce body weight and fat deposition. The biosafety is evaluated in vitro at the cellular level, based on ISO-10993, and further checked by animal study. We do believe that the TA could have a greater potential to be developed into a safe health supplement to manage obesity and for body-weight control.
肥胖是全球最常见的健康问题。然而，到目前为止，尚无有效的方法来管理肥胖或控制体重。本研究的目的是开发一种可食用凝胶作为健康补充剂，它能暂时附着在肠道黏液上，形成吸收屏障以阻止营养物质吸收。我们将藻酸盐用硫醇基团修饰为硫醇化藻酸盐（TA），其可在黏膜层停留更长时间以减少营养物质吸收。在本研究中，成功合成了TA，并证明其在体外和体内均具有良好的黏膜黏附性，可作为营养物质吸收的屏障。体内成像系统（IVIS）结果表明，合成的TA可在24小时内从胃肠道排出。动物研究表明，每日口服TA可有效减轻体重和减少脂肪沉积。基于ISO - 10993在细胞水平对生物安全性进行了体外评估，并通过动物研究进一步验证。我们坚信，TA有更大的潜力被开发成一种安全的健康补充剂，用于管理肥胖和控制体重。
