小儿患者亚麻醉剂量静脉输注氯胺酮治疗神经性疼痛和伴有自杀倾向抑郁症的病例报告
Case Report of Subanesthetic Intravenous Ketamine Infusion for the Treatment of Neuropathic Pain and Depression with Suicidal Features in a Pediatric Patient.
作者信息
Weber Garret, Yao JuHan, Binns Shemeica, Namkoong Shinae
机构信息
Department of Anesthesiology, New York Medical College, Valhalla, NY, USA.
出版信息
Case Rep Anesthesiol. 2018 Jul 26;2018:9375910. doi: 10.1155/2018/9375910. eCollection 2018.
Abstract
Chronic neuropathic pain and depression are often comorbid. Ketamine has been used to treat refractory pain. There is emerging evidence for use in depression. We present a case of a pediatric patient who was successfully treated with subanesthetic intravenous ketamine infusion for chronic neuropathic pain and suicidality.
摘要
慢性神经性疼痛和抑郁症常常合并存在。氯胺酮已被用于治疗难治性疼痛。越来越多的证据表明其可用于治疗抑郁症。我们报告一例儿科患者，该患者通过亚麻醉剂量静脉输注氯胺酮成功治疗了慢性神经性疼痛和自杀倾向。
相似文献
1
Case Report of Subanesthetic Intravenous Ketamine Infusion for the Treatment of Neuropathic Pain and Depression with Suicidal Features in a Pediatric Patient.小儿患者亚麻醉剂量静脉输注氯胺酮治疗神经性疼痛和伴有自杀倾向抑郁症的病例报告
Case Rep Anesthesiol. 2018 Jul 26;2018:9375910. doi: 10.1155/2018/9375910. eCollection 2018.
2
Analgesic effect of subanesthetic intravenous ketamine in refractory neuropathic pain: a case report.鞘内注射亚麻醉剂量氯胺酮治疗难治性神经病理性疼痛的镇痛效果：一例报告。
Pain Med. 2010 Jun;11(6):946-50. doi: 10.1111/j.1526-4637.2010.00863.x.
3
Continuous Dentoalveolar Neuropathic Pain Response to Repeated Intravenous Ketamine Infusions: A Case Report.连续的牙牙槽神经性疼痛对重复静脉注射氯胺酮的反应：一例报告。
J Oral Facial Pain Headache. 2018;32(2):e22-e27. doi: 10.11607/ofph.2023.
4
Case Reports Showing a Long-Term Effect of Subanesthetic Ketamine Infusion in Reducing l-DOPA-Induced Dyskinesias.病例报告显示亚麻醉剂量氯胺酮输注在减轻左旋多巴诱发的运动障碍方面具有长期效果。
Case Rep Neurol. 2016 Feb 26;8(1):53-8. doi: 10.1159/000444278. eCollection 2016 Jan-Apr.
5
Subanesthetic ketamine infusion therapy: a retrospective analysis of a novel therapeutic approach to complex regional pain syndrome.亚麻醉剂量氯胺酮输注疗法：对复杂性区域疼痛综合征一种新型治疗方法的回顾性分析
Pain Med. 2004 Sep;5(3):263-75. doi: 10.1111/j.1526-4637.2004.04043.x.
6
Subanesthetic ketamine infusions for the treatment of children and adolescents with chronic pain: a longitudinal study.亚麻醉剂量氯胺酮输注治疗儿童和青少年慢性疼痛的纵向研究。
BMC Pediatr. 2015 Dec 1;15:198. doi: 10.1186/s12887-015-0515-4.
7
Subanesthetic ketamine for pain management in hospitalized children, adolescents, and young adults: a single-center cohort study.用于住院儿童、青少年和青年疼痛管理的亚麻醉剂量氯胺酮：一项单中心队列研究。
J Pain Res. 2017 Apr 5;10:787-795. doi: 10.2147/JPR.S131156. eCollection 2017.
8
[Ketamine in the therapy of chronic pain and depression].[氯胺酮在慢性疼痛和抑郁症治疗中的应用]
Wien Med Wochenschr. 2019 Nov;169(15-16):367-376. doi: 10.1007/s10354-019-0695-x. Epub 2019 Apr 12.
9
Case report: efficacy and tolerability of ketamine in opioid-refractory cancer pain.病例报告：氯胺酮治疗阿片类药物难治性癌痛的疗效与耐受性
J Pain Palliat Care Pharmacother. 2014 Sep;28(3):233-42. doi: 10.3109/15360288.2014.938881. Epub 2014 Aug 7.
10
A Case Report: Subanesthetic Ketamine Infusion for Treatment of Cancer-Related Pain Produces Urinary Urge Incontinence.病例报告：亚麻醉剂量氯胺酮输注治疗癌症相关疼痛导致急迫性尿失禁。
A A Case Rep. 2017 May 1;8(9):219-221. doi: 10.1213/XAA.0000000000000472.
引用本文的文献
1
Interventions for suicidal and self-injurious related behaviors in adolescents with psychiatric disorders: a systematic review and meta-analysis.针对患有精神疾病青少年的自杀及自我伤害相关行为的干预措施：一项系统综述与荟萃分析
Transl Psychiatry. 2025 Mar 5;15(1):73. doi: 10.1038/s41398-025-03278-7.
2
Exploring the Therapeutic Potential of N-Methyl-D-Aspartate Receptor Antagonists in Neuropathic Pain Management.探讨 N-甲基-D-天冬氨酸受体拮抗剂在神经性疼痛管理中的治疗潜力。
Int J Mol Sci. 2024 Oct 16;25(20):11111. doi: 10.3390/ijms252011111.
3
Ketamine for mood disorders, anxiety, and suicidality in children and adolescents: a systematic review.氯胺酮用于儿童和青少年的情绪障碍、焦虑及自杀倾向：一项系统综述
Eur Child Adolesc Psychiatry. 2025 Jan;34(1):141-157. doi: 10.1007/s00787-024-02458-y. Epub 2024 May 16.
4
Effect of Acute Ketamine Treatment on Sympathetic Regulation Indexed by Electrodermal Activity in Adolescent Major Depression.急性氯胺酮治疗对青少年重度抑郁症患者以皮肤电活动为指标的交感神经调节的影响。
Pharmaceuticals (Basel). 2024 Mar 10;17(3):358. doi: 10.3390/ph17030358.
5
Use of ketamine for depression and suicidality in cancer and terminal patients: Review of current data.氯胺酮在癌症及终末期患者抑郁症和自杀倾向治疗中的应用：当前数据综述
AIMS Public Health. 2023 Jul 21;10(3):610-626. doi: 10.3934/publichealth.2023043. eCollection 2023.
6
Short-term cognitive effects of repeated-dose esketamine in adolescents with major depressive disorder and suicidal ideation: a randomized controlled trial.重复剂量艾司氯胺酮对患有重度抑郁症和自杀意念的青少年的短期认知影响：一项随机对照试验。
Child Adolesc Psychiatry Ment Health. 2023 Sep 14;17(1):108. doi: 10.1186/s13034-023-00647-2.
7
Ketamine-assisted psychotherapy in adolescents with multiple psychiatric diagnoses.氯胺酮辅助心理治疗用于患有多种精神疾病诊断的青少年。
Front Psychiatry. 2023 Mar 30;14:1141988. doi: 10.3389/fpsyt.2023.1141988. eCollection 2023.
8
The efficacy and safety of esketamine in the treatment of major depressive disorder with suicidal ideation: study protocol for a randomized controlled trial.依他佐辛治疗伴有自杀意念的重性抑郁障碍的疗效和安全性：一项随机对照试验的研究方案。
BMC Psychiatry. 2022 Nov 30;22(1):744. doi: 10.1186/s12888-022-04388-y.
9
Efficacy of ketamine for comorbid depression and acute or chronic pain: A systematic review.氯胺酮治疗共病性抑郁症及急慢性疼痛的疗效：一项系统评价
Front Pain Res (Lausanne). 2022 Oct 24;3:1022767. doi: 10.3389/fpain.2022.1022767. eCollection 2022.
10
Low-dose ketamine infusions reduce opioid use in pediatric and young adult oncology patients.低剂量氯胺酮输注可减少儿科和青年成人生肿瘤患者的阿片类药物使用。
Pediatr Blood Cancer. 2022 Sep;69(9):e29693. doi: 10.1002/pbc.29693. Epub 2022 Apr 4.
本文引用的文献
1
Emerging therapies for neuropathic pain: new molecules or new indications for old treatments?新兴的神经病理性疼痛治疗方法：新分子还是旧疗法的新适应证？
Pain. 2018 Mar;159(3):576-582. doi: 10.1097/j.pain.0000000000001136.
2
Use of ketamine for acute suicidal ideation in a patient with chronic pain on prescribed cannabinoids.氯胺酮在一名长期服用大麻素类药物且患有慢性疼痛的患者中用于治疗急性自杀意念。
BMJ Case Rep. 2017 Nov 12;2017:bcr-2017-222059. doi: 10.1136/bcr-2017-222059.
3
Opioids for chronic non-cancer pain in children and adolescents.用于儿童和青少年慢性非癌性疼痛的阿片类药物。
Cochrane Database Syst Rev. 2017 Jul 26;7(7):CD012538. doi: 10.1002/14651858.CD012538.pub2.
4
Ketamine: An Update on Cellular and Subcellular Mechanisms with Implications for Clinical Practice.氯胺酮：细胞及亚细胞机制的最新进展及其对临床实践的意义
Pain Physician. 2017 Feb;20(2):E285-E301.
5
What is the mechanism of Ketamine's rapid-onset antidepressant effect? A concise overview of the surprisingly large number of possibilities.氯胺酮快速起效的抗抑郁作用机制是什么？对大量惊人可能性的简要概述。
J Clin Pharm Ther. 2017 Apr;42(2):147-154. doi: 10.1111/jcpt.12497. Epub 2017 Jan 22.
6
Meta-analysis of short- and mid-term efficacy of ketamine in unipolar and bipolar depression.氯胺酮治疗单相和双相抑郁的短期和中期疗效的荟萃分析。
Psychiatry Res. 2015 Dec 15;230(2):682-8. doi: 10.1016/j.psychres.2015.10.032. Epub 2015 Oct 30.
7
Neuropathic pain: principles of diagnosis and treatment.神经病理性疼痛：诊断与治疗原则。
Mayo Clin Proc. 2015 Apr;90(4):532-45. doi: 10.1016/j.mayocp.2015.01.018.
8
Ketamine as a potential treatment for suicidal ideation: a systematic review of the literature.氯胺酮作为自杀意念的潜在治疗方法：文献系统综述
Drugs R D. 2015 Mar;15(1):37-43. doi: 10.1007/s40268-015-0081-0.
9
National trends in the treatment for depression from 1998 to 2007.1998年至2007年抑郁症治疗的全国趋势。
Arch Gen Psychiatry. 2010 Dec;67(12):1265-73. doi: 10.1001/archgenpsychiatry.2010.151.
10
Analgesic effect of subanesthetic intravenous ketamine in refractory neuropathic pain: a case report.鞘内注射亚麻醉剂量氯胺酮治疗难治性神经病理性疼痛的镇痛效果：一例报告。
Pain Med. 2010 Jun;11(6):946-50. doi: 10.1111/j.1526-4637.2010.00863.x.
Zotero 插件