Patel Rachel C, Wang Jie, Hwang Thomas S, Zhang Miao, Gao Simon S, Pennesi Mark E, Bailey Steven T, Lujan Brandon J, Wang Xiaogang, Wilson David J, Huang David, Jia Yali
Casey Eye Institute, Oregon Health & Science University, 3375 SW Terwilliger Blvd, Portland, OR 97239.
University of Massachusetts Medical School, 55 Lake Ave North, Worcester, MA 01655.
Ophthalmol Retina. 2018 Aug;2(8):816-826. doi: 10.1016/j.oret.2017.11.010. Epub 2018 Jan 10.
To evaluate the projection-resolved (PR) optical coherence tomography angiography (OCTA) algorithm in detecting plexus-specific vascular abnormalities in retinal pathologies.
Cross-sectional observational clinical study.
Patients diagnosed with retinal vascular diseases and healthy volunteers.
Eyes were imaged using an OCT system operating at 840 nm and employing the split-spectrum amplitude decorrelation algorithm. A novel algorithm suppressed projection artifacts inherent to OCTA. The volumetric scans were segmented and visualized on different plexuses.
Qualitative observation of vascular abnormalities on both cross-sectional and PR-OCTA images.
Eight illustrative cases are reported. In cases of diabetic retinopathy, retinal vessel occlusion, and retinitis pigmentosa, PR-OCTA detected retinal nonperfusion regions within deeper retinal plexuses not visualized by conventional OCTA. In age-related macular degeneration, cross-sectional PR-OCTA permitted the classification of choroidal neovascularization, and, in a case of retinal angiomatous proliferation, identified a vertical vessel contiguous with the deep capillary plexus. In macular telangiectasia, PR-OCTA detected a diving perifoveal vein and delineated subretinal neovascularization.
Application of PR-OCTA promises to improve sensitive, accurate evaluation of individual vascular plexuses in multiple retinal diseases.
评估投影分辨（PR）光学相干断层扫描血管造影（OCTA）算法在检测视网膜病变中特定神经丛血管异常方面的作用。
横断面观察性临床研究。
被诊断患有视网膜血管疾病的患者和健康志愿者。
使用工作在840nm的OCT系统并采用分裂谱幅度去相关算法对眼睛进行成像。一种新算法抑制了OCTA固有的投影伪影。对容积扫描进行分割并在不同神经丛上可视化。
在横断面和PR-OCTA图像上对血管异常进行定性观察。
报告了8个典型病例。在糖尿病性视网膜病变、视网膜血管阻塞和视网膜色素变性病例中，PR-OCTA检测到传统OCTA未显示的更深层视网膜神经丛内的视网膜无灌注区域。在年龄相关性黄斑变性中，横断面PR-OCTA可对脉络膜新生血管进行分类，并且在一例视网膜血管瘤样增生病例中，识别出一条与深层毛细血管丛相连的垂直血管。在黄斑毛细血管扩张症中，PR-OCTA检测到一条向心性黄斑周围静脉并勾勒出视网膜下新生血管。
PR-OCTA的应用有望改善对多种视网膜疾病中单个血管神经丛的敏感、准确评估。
