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不同的嘌呤受体介导腺苷对大鼠肥大细胞中伴刀豆球蛋白A诱导的介质释放和环磷酸腺苷反应的增强作用。

Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells.

作者信息

Hughes P J, Church M K

出版信息

Agents Actions. 1986 Apr;18(1-2):81-4. doi: 10.1007/BF01987989.

DOI:10.1007/BF01987989
PMID:3014845
Abstract

Adenosine caused a concentration-related enhancement of concanavalin A (Con A)-induced 5-hydroxytryptamine (5-HT) release from rat purified peritoneal mast cells. This was accompanied by an enhancement and prolongation of the cyclic AMP response to Con A. The cyclic AMP response but not enhancement of 5-HT release was blocked by 8-phenyltheophylline suggesting the two events to be unrelated. The effects of AMP and ADP, adenosine analogues and adenosine uptake inhibitors suggest the enhancement of 5-HT release to be mediated by a P1-cell surface purinoceptor which does not show the characteristics of either A1 or A2 subtypes.

摘要

腺苷可使伴刀豆球蛋白A（Con A）诱导的大鼠纯化腹膜肥大细胞释放5-羟色胺（5-HT）增强，且呈浓度依赖性。这伴随着对Con A的环磷酸腺苷（cAMP）反应增强和延长。8-苯基茶碱可阻断cAMP反应，但不影响5-HT释放的增强，提示这两个事件无关。腺苷类似物AMP和ADP以及腺苷摄取抑制剂的作用表明，5-HT释放的增强是由P1细胞表面嘌呤受体介导的，该受体不具有A1或A2亚型的特征。

相似文献

1
Separate purinoceptors mediate enhancement by adenosine of concanavalin A-induced mediator release and the cyclic AMP response in rat mast cells.不同的嘌呤受体介导腺苷对大鼠肥大细胞中伴刀豆球蛋白A诱导的介质释放和环磷酸腺苷反应的增强作用。
Agents Actions. 1986 Apr;18(1-2):81-4. doi: 10.1007/BF01987989.
2
Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells.关于介导腺苷对大鼠肥大细胞IgE依赖性介质释放的环磷酸腺苷非依赖性增强作用的受体的研究。
Br J Pharmacol. 1986 Jan;87(1):233-42. doi: 10.1111/j.1476-5381.1986.tb10176.x.
3
Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP-independent cell-surface action.腺苷通过一种新的不依赖环磷酸腺苷的细胞表面作用增强大鼠肥大细胞的免疫性组胺释放。
Br J Pharmacol. 1985 May;85(1):3-5. doi: 10.1111/j.1476-5381.1985.tb08823.x.
4
The effect of adenosine and its analogues on cyclic AMP changes and histamine secretion from rat peritoneal mast cells stimulated by various ligands.腺苷及其类似物对由各种配体刺激的大鼠腹膜肥大细胞中环磷酸腺苷（cAMP）变化和组胺分泌的影响。
Biochem Pharmacol. 1986 Apr 15;35(8):1373-9. doi: 10.1016/0006-2952(86)90284-4.
5
Role of cyclic AMP in the induction of histamine secretion from mast cells.环磷酸腺苷在肥大细胞组胺分泌诱导中的作用。
Agents Actions. 1985 Apr;16(3-4):126-8. doi: 10.1007/BF01983118.
6
Dual actions of adenosine on rat peritoneal mast cells.腺苷对大鼠腹膜肥大细胞的双重作用。
Naunyn Schmiedebergs Arch Pharmacol. 1987 May;335(5):555-60. doi: 10.1007/BF00169124.
7
The effects of adenosine and of some adenosine analogues on the concanavalin A-or acetylcholine-induced histamine release from human adenoidal mast cells.
Agents Actions. 1985 Apr;16(3-4):141-3. doi: 10.1007/BF01983122.
8
Postnatal changes in response to adenosine and adenine nucleotides in rat duodenum.大鼠十二指肠对腺苷和腺嘌呤核苷酸反应的产后变化。
Br J Pharmacol. 1989 Aug;97(4):1111-8. doi: 10.1111/j.1476-5381.1989.tb12568.x.
9
Adenosine inhibits and potentiates IgE-dependent histamine release from human lung mast cells by an A2-purinoceptor mediated mechanism.腺苷通过A2嘌呤受体介导的机制抑制并增强人肺肥大细胞中IgE依赖的组胺释放。
Biochem Pharmacol. 1984 Dec 1;33(23):3847-52. doi: 10.1016/0006-2952(84)90050-9.
10
Purinoceptors in the rat heart.大鼠心脏中的嘌呤受体。
Br J Pharmacol. 1987 Jan;90(1):219-27. doi: 10.1111/j.1476-5381.1987.tb16843.x.

引用本文的文献

1
Inosine binds to A3 adenosine receptors and stimulates mast cell degranulation.肌苷与A3腺苷受体结合并刺激肥大细胞脱颗粒。
J Clin Invest. 1997 Dec 1;100(11):2849-57. doi: 10.1172/JCI119833.
2
Synergistic effects of calcium-mobilizing agents and adenosine on histamine release from rat peritoneal mast cells.钙动员剂与腺苷对大鼠腹膜肥大细胞组胺释放的协同作用。
Br J Pharmacol. 1989 Dec;98(4):1392-8. doi: 10.1111/j.1476-5381.1989.tb12689.x.
3
Dual actions of adenosine on rat peritoneal mast cells.腺苷对大鼠腹膜肥大细胞的双重作用。

本文引用的文献

1
Role of adenylate cyclase in immunologic release of mediators from rat mast cells: agonist and antagonist effects of purine- and ribose-modified adenosine analogs.腺苷酸环化酶在大鼠肥大细胞介质免疫释放中的作用：嘌呤和核糖修饰的腺苷类似物的激动剂和拮抗剂作用
Proc Natl Acad Sci U S A. 1980 Nov;77(11):6800-4. doi: 10.1073/pnas.77.11.6800.
2
The relationship between cyclic AMP changes and histamine release from basophil-rich human leucocytes.环磷酸腺苷（cAMP）变化与富含嗜碱性粒细胞的人白细胞组胺释放之间的关系。
Biochem Pharmacol. 1983 Sep 1;32(17):2557-63. doi: 10.1016/0006-2952(83)90018-7.
3
Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP-independent cell-surface action.
Naunyn Schmiedebergs Arch Pharmacol. 1987 May;335(5):555-60. doi: 10.1007/BF00169124.
4
Adenosine bronchoconstriction in asthma: investigations into its possible mechanism of action.哮喘中的腺苷支气管收缩：对其可能作用机制的研究。
Br J Clin Pharmacol. 1990;30 Suppl 1(Suppl 1):89S-98S. doi: 10.1111/j.1365-2125.1990.tb05474.x.
腺苷通过一种新的不依赖环磷酸腺苷的细胞表面作用增强大鼠肥大细胞的免疫性组胺释放。
Br J Pharmacol. 1985 May;85(1):3-5. doi: 10.1111/j.1476-5381.1985.tb08823.x.
4
Modulation of cyclic AMP in purified rat mast cells. III. Studies on the effects of concanavalin A and anti-IgE on cyclic AMP concentrations during histamine release.纯化大鼠肥大细胞中环磷酸腺苷的调节。III. 刀豆球蛋白A和抗IgE对组胺释放过程中环磷酸腺苷浓度影响的研究。
J Immunol. 1976 Sep;117(3):713-6.