通过靶向调节米色脂肪细胞的因素来对抗肥胖。
Fighting obesity by targeting factors regulating beige adipocytes.
机构信息
Metabolic Biology Graduate Program and Department of Nutritional Sciences and Toxicology, University of California Berkeley, Berkeley.
The Diabetes Center and Department of Medicine, University of California San Francisco, San Francisco, California, USA.
出版信息
Curr Opin Clin Nutr Metab Care. 2018 Nov;21(6):437-443. doi: 10.1097/MCO.0000000000000509.
Abstract
PURPOSE OF REVIEW
The current review provides an update on secreted factors and mechanisms that promote a thermogenic program in beige adipocytes, and their potential roles as therapeutic targets to fight obesity.
RECENT FINDINGS
We outline recent studies revealing unrecognized mechanisms controlling beige adipocyte physiology, and summarize in particular those that underlie beige thermogenesis independently of classical uncoupling. We also update strategies aimed at fostering beige adipogenesis and white-to beige adipocyte conversion. Finally, we summarize newly identified endogenous secreted factors that promote the thermogenic activation of beige adipocytes and discuss their therapeutic potential.
SUMMARY
The identification of novel endogenous factors that promote beiging and regulate beige adipocyte-specific physiological pathways opens up new avenues for therapeutic engineering targeting obesity and related metabolic disorders.
摘要
目的综述
本综述介绍了促进米色脂肪细胞产热程序的分泌因子和机制，及其作为治疗肥胖症靶点的潜在作用。
最新发现
我们概述了最近的研究揭示了控制米色脂肪细胞生理学的未被识别的机制，并特别总结了那些独立于经典解偶联作用控制米色产热的机制。我们还更新了促进米色脂肪生成和白色脂肪向米色脂肪细胞转化的策略。最后，我们总结了新发现的促进米色脂肪细胞产热的内源性分泌因子，并讨论了它们的治疗潜力。
总结
鉴定出促进米色形成和调节米色脂肪细胞特异性生理途径的新型内源性因子，为靶向肥胖症和相关代谢紊乱的治疗工程开辟了新途径。
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本文引用的文献
1
Genetic and epigenetic control of adipose development.脂肪组织发育的遗传和表观遗传调控。
Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Jan;1864(1):3-12. doi: 10.1016/j.bbalip.2018.04.016. Epub 2018 Apr 25.
2
Mitophagy controls beige adipocyte maintenance through a Parkin-dependent and UCP1-independent mechanism.线粒体自噬通过一种依赖 Parkin 和不依赖 UCP1 的机制来控制米色脂肪细胞的维持。
Sci Signal. 2018 Apr 24;11(527):eaap8526. doi: 10.1126/scisignal.aap8526.
3
Warming Induces Significant Reprogramming of Beige, but Not Brown, Adipocyte Cellular Identity.升温显著诱导米色脂肪细胞，但不诱导棕色脂肪细胞的细胞身份重编程。
Cell Metab. 2018 May 1;27(5):1121-1137.e5. doi: 10.1016/j.cmet.2018.03.005. Epub 2018 Apr 12.
4
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