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脂肪生成建模:现状与未来展望。

Modeling Adipogenesis: Current and Future Perspective.

机构信息

Department of Anatomy, Cell Biology, and Physiological Sciences, Faculty of Medicine, American University of Beirut, 1107 2260 Beirut, Lebanon.

Laboratory for Immuno Bioengineering Research and Applications, Division of Engineering, New York University Abu Dhabi, 2460 Abu Dhabi, UAE.

出版信息

Cells. 2020 Oct 20;9(10):2326. doi: 10.3390/cells9102326.

Abstract

Adipose tissue is contemplated as a dynamic organ that plays key roles in the human body. Adipogenesis is the process by which adipocytes develop from adipose-derived stem cells to form the adipose tissue. Adipose-derived stem cells' differentiation serves well beyond the simple goal of producing new adipocytes. Indeed, with the current immense biotechnological advances, the most critical role of adipose-derived stem cells remains their tremendous potential in the field of regenerative medicine. This review focuses on examining the physiological importance of adipogenesis, the current approaches that are employed to model this tightly controlled phenomenon, and the crucial role of adipogenesis in elucidating the pathophysiology and potential treatment modalities of human diseases. The future of adipogenesis is centered around its crucial role in regenerative and personalized medicine.

摘要

脂肪组织被认为是一种具有关键作用的动态器官,在人体中发挥着重要作用。脂肪生成是指脂肪细胞从脂肪来源的干细胞中发育形成脂肪组织的过程。脂肪来源干细胞的分化不仅仅是为了产生新的脂肪细胞这一简单目标。事实上,随着当前生物技术的巨大进步,脂肪来源干细胞最重要的作用仍然是它们在再生医学领域的巨大潜力。本综述重点探讨了脂肪生成的生理重要性、目前用于模拟这一严格控制现象的方法,以及脂肪生成在阐明人类疾病的病理生理学和潜在治疗方法方面的关键作用。脂肪生成的未来集中在它在再生医学和个性化医学中的关键作用上。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7e99/7590203/463434049538/cells-09-02326-g001.jpg

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