Escuela de Nutrición y dietética, Facultad de Ciencias para el cuidado de la Salud, Universidad San Sebastián, Concepción, Chile.
Departamento de Nutrición, Diabetes y Metabolismo, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile.
Nutrition. 2018 Oct;54:105-110. doi: 10.1016/j.nut.2018.03.001. Epub 2018 Mar 27.
The aim of this study was to assess the association between the single-nucleotide polymorphism rs9939609 in the FTO gene and homeostatic/non-homeostatic eating behavior patterns in Chilean children.
A cross-sectional study was conducted in 258 children (44% female; 8-14 y of age). Anthropometric measurements (weight, height, Z-score of height, body mass index, and waist circumference) were performed. Eating behavior was assessed using the Eating in Absence of Hunger Questionnaire; the Child Eating Behavior Questionnaire; the Three Factor Eating Questionnaire, and the Food Reinforcement Value Questionnaire. Genotype of rs9939609 was determined by a Taqman assay. Association of rs9939609 with eating behavior was assessed using non-parametric tests.
Allelic frequencies of rs9939609 were estimated as 77% for the A allele and 23% for the T allele. We found that normal-weight girl A carriers had higher scores of Satiety Responsiveness and Slowness on the Eating subscale. Normal-weight boy A carriers showed significantly higher scores on the Negative Affect and lower scores of the Desire to Drink subscale. In overweight children, A carriers showed higher scores on the Food Responsiveness, Emotional Overeating, Enjoyment of Food, and Food Choice subscales and lower scores on the Satiety- Responsiveness and Slowness in Eating subscales. In obese children, we found higher scores on the Cognitive Restrained subscale and lower Food Choice.
The rs9939609 A allele of the FTO gene is associated with eating behavior traits and may predispose to obesity.
本研究旨在评估 FTO 基因中单核苷酸多态性 rs9939609 与智利儿童的稳态/非稳态进食行为模式之间的关联。
进行了一项横断面研究，共纳入 258 名儿童（44%为女性；8-14 岁）。进行了体格测量（体重、身高、身高 Z 评分、体重指数和腰围）。采用饥饿感缺失进食行为问卷、儿童进食行为问卷、三因素进食问卷和食物强化价值问卷评估进食行为。采用 Taqman 检测法测定 rs9939609 基因型。采用非参数检验评估 rs9939609 与进食行为的相关性。
rs9939609 的等位基因频率估计为 A 等位基因 77%，T 等位基因 23%。我们发现，正常体重女孩 A 携带者在进食分量感和进食缓慢维度上的得分较高。正常体重男孩 A 携带者在负性情绪和渴望饮水维度上的得分较低。超重儿童中，A 携带者在食物反应性、情绪性进食、享受食物和食物选择维度上的得分较高，在饱腹感和进食缓慢维度上的得分较低。在肥胖儿童中，我们发现认知控制维度上的得分较高，食物选择维度上的得分较低。
FTO 基因的 rs9939609 A 等位基因与进食行为特征相关，可能导致肥胖易感性。
