Kim Ju Yeong, Kim Eun-Min, Yi Myung-Hee, Lee Jinyoung, Lee Seogwon, Hwang Younjee, Yong Dongeun, Sohn Woon-Mok, Yong Tai-Soon
Department of Environmental Medical Biology, Institute of Tropical Medicine, Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Seoul, 03722, South Korea; Brain Korea 21 PLUS Project for Medical Science, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Department of Environmental Medical Biology, Institute of Tropical Medicine, Arthropods of Medical Importance Resource Bank, Yonsei University College of Medicine, Seoul, 03722, South Korea.
Exp Parasitol. 2018 Oct;193:45-50. doi: 10.1016/j.exppara.2018.08.002. Epub 2018 Aug 25.
Helminth infection can alleviate immune-mediated disorders such as allergies and autoimmune diseases, by altering the gut microbiome. However, changes in gut microbiome due to intestinal trematodes remain unelucidated. Here, we evaluated the changes in the gut microbiome of ICR mice infected with Metagonimus yokogawai, a hypo-virulent intestinal trematode. Four weeks after infection, mouse cecal content was analyzed by 16S rRNA amplicon analysis. Although there was no apparent difference in species richness and diversity, the microbiome composition was different in the infected and control groups. Furthermore, several Lactobacillus species with known immunomodulatory role in immune-mediated diseases were increased in the infected group.
蠕虫感染可通过改变肠道微生物群来缓解免疫介导的疾病，如过敏和自身免疫性疾病。然而，肠道吸虫引起的肠道微生物群变化仍不清楚。在这里，我们评估了感染低毒力肠道吸虫横川后睾吸虫的ICR小鼠肠道微生物群的变化。感染四周后，通过16S rRNA扩增子分析对小鼠盲肠内容物进行分析。虽然物种丰富度和多样性没有明显差异，但感染组和对照组的微生物群组成不同。此外，感染组中几种在免疫介导疾病中具有已知免疫调节作用的乳酸杆菌种类有所增加。
