Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Institute of Biomedicine, Research Centre for Integrative Physiology and Pharmacology, Turku Center for Disease Modeling, University of Turku, Turku, Finland.
Mol Cell Endocrinol. 2019 Jun 1;489:9-31. doi: 10.1016/j.mce.2018.08.004. Epub 2018 Aug 25.
Abnormal synthesis and metabolism of sex steroids is involved in the pathogenesis of various human diseases, such as endometriosis and cancers arising from the breast and uterus. Steroid biosynthesis is a multistep enzymatic process proceeding from cholesterol to highly active sex steroids via different intermediates. Human Hydroxysteroid (17beta) dehydrogenase 1 (HSD17B1) enzyme shows a high capacity to produce the highly active estrogen, estradiol, from a precursor hormone, estrone. However, the enzyme may also play a role in other steps of the steroid biosynthesis pathway. In this article, we have reviewed the literature on HSD17B1, and summarize the role of the enzyme in hormone-dependent diseases in women as evidenced by preclinical studies.
异常的性激素合成和代谢与各种人类疾病的发病机制有关，如子宫内膜异位症和乳腺癌、子宫癌。甾体生物合成是一个多步骤的酶促过程，从胆固醇到不同中间产物的高活性性激素。人羟甾体（17β）脱氢酶 1（HSD17B1）酶具有将前体激素雌酮转化为高活性雌激素雌二醇的高能力。然而，该酶也可能在甾体生物合成途径的其他步骤中发挥作用。本文综述了 HSD17B1 的文献，并总结了该酶在女性激素依赖性疾病中的作用，这些作用已被临床前研究证实。
