Pharmaceutical Botany Laboratory, College of Pharmacy, Chung-Ang University, Heukseok-dong, Dongjak-gu, Seoul 156-756, Korea.
Molecules. 2018 Aug 27;23(9):2148. doi: 10.3390/molecules23092148.
Inhibition of the formation of advanced glycation end products (AGEs) is an attractive strategy in diabetes treatment. extracts were suggested to have antidiabetic effects. However, studies on the components of are lacking, and there is no report on the inhibitory effects of on the formation of AGEs. Therefore, extracts and fractions were tested for their inhibitory effects on α-glucosidase and AGEs formation in two systems (bovine serum albumin (BSA)⁻glucose and BSA⁻methylglyoxal (MGO)). Bioassay-guided isolation of compounds from led to six flavones (⁻) and four hydroxycinnamic acid derivatives (⁻). Compound exhibited the highest inhibitory activity against α-glucosidase and AGEs formation and had the highest content in extract. All compounds except compound showed a stronger inhibition than the positive control in the BSA-glucose and BSA-MGO system. In addition, showed a higher content of bioactive compounds and stronger inhibition of AGE formation and α-glucosidase activity than . Our study demonstrated the preventive and therapeutic efficacy of and its potential use as a cost-effective phytopharmaceutical in complementary therapy against type-2 diabetes and its complications.
抑制晚期糖基化终产物（AGEs）的形成是糖尿病治疗的一种有吸引力的策略。 提取物被认为具有抗糖尿病作用。然而， 的成分研究尚缺乏，且尚无关于 对 AGEs 形成的抑制作用的报道。因此，对 提取物及其馏分在两个体系（牛血清白蛋白（BSA）-葡萄糖和 BSA-甲基乙二醛（MGO））中对α-葡萄糖苷酶和 AGEs 形成的抑制作用进行了测试。从 中进行基于生物测定的化合物分离，得到了六种黄酮（⁻）和四种羟基肉桂酸衍生物（⁻）。化合物 对α-葡萄糖苷酶和 AGEs 形成的抑制活性最高，且在 提取物中的含量最高。除化合物 外，所有化合物在 BSA-葡萄糖和 BSA-MGO 体系中的抑制作用均强于阳性对照。此外， 显示出比 更高的生物活性化合物含量以及更强的 AGE 形成和 α-葡萄糖苷酶活性抑制作用。我们的研究表明 具有预防和治疗功效，并可能作为一种具有成本效益的植物药在 2 型糖尿病及其并发症的补充治疗中使用。
