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The m6A reader YTHDF2 protects vascular smooth muscle cells against the osteogenic differentiation through targeting Runx2.m6A 阅读器 YTHDF2 通过靶向 Runx2 保护血管平滑肌细胞免受成骨分化。
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tRNA mA modification regulate HSC maintenance and self-renewal via mTORC1 signaling.tRNA mA 修饰通过 mTORC1 信号调节造血干细胞的维持和自我更新。
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Regulatory roles of N6-methyladenosine (mA) methylation in RNA processing and non-communicable diseases.N6-甲基腺苷(m6A)甲基化在 RNA 处理和非传染性疾病中的调控作用。
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Loss of YTHDF2-mediated mA-dependent mRNA clearance facilitates hematopoietic stem cell regeneration.

作者信息

Wang Hu, Zuo Hongna, Liu Jin, Wen Fei, Gao Yawei, Zhu Xudong, Liu Bo, Xiao Feng, Wang Wengong, Huang Gang, Shen Bin, Ju Zhenyu

机构信息

Key Laboratory of Regenerative Medicine of Ministry of Education, Institute of Aging and Regenerative Medicine, Jinan University, Guangzhou, Guangdong, China.

Institute of Aging Research, Hangzhou Normal University School of Medicine, Hangzhou, Zhejiang, 311121, China.

出版信息

Cell Res. 2018 Oct;28(10):1035-1038. doi: 10.1038/s41422-018-0082-y. Epub 2018 Aug 27.

DOI:10.1038/s41422-018-0082-y
PMID:30150673
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6170435/
Abstract
摘要