Inflammatory Bowel Disease Clinic, Department of Gastroenterology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, Mexico.
PECEM (Combined Study Plan in Medicine), Faculty of Medicine, Universidad Nacional Autónoma de México, Mexico City, Mexico.
Mediators Inflamm. 2018 Jul 29;2018:6570371. doi: 10.1155/2018/6570371. eCollection 2018.
The transient receptor potential vanilloid 1 (TRPV1) may play a role in the pathogenesis of ulcerative colitis (UC). The aim of the study was to determine the gene and protein expression of TRPV1 in UC patients and noninflamed controls. Gene expression was performed by RT-PCR, and protein expression was performed by immunohistochemistry. The gene expression of TRPV1 was significantly increased in the remission UC group compared to active UC patients ( = 0.002), and an upregulation of the TRPV1 gene was associated with clinical outcomes such as age at diagnosis (<40 years) ( = 0.02) and clinical disease course characterized by relapsing and continuous activity ( = 0.07). TRPV1 immunoreactive cells were conspicuously higher in all intestinal layers from active UC patients compared with noninflamed control tissue. These findings suggest that TRPV1 might be involved in UC pathogenesis.
瞬时受体电位香草素 1 (TRPV1) 可能在溃疡性结肠炎 (UC) 的发病机制中起作用。本研究旨在确定 UC 患者和非炎症对照中 TRPV1 的基因和蛋白表达。通过 RT-PCR 进行基因表达，通过免疫组织化学进行蛋白表达。与活动期 UC 患者相比，缓解期 UC 患者的 TRPV1 基因表达显著增加 ( = 0.002)，TRPV1 基因的上调与诊断时年龄 (<40 岁) ( = 0.02) 和以复发和持续活动为特征的临床病程 ( = 0.07) 等临床结果相关。与非炎症对照组织相比，活动期 UC 患者的所有肠层中 TRPV1 免疫反应性细胞明显更高。这些发现表明 TRPV1 可能参与 UC 的发病机制。
