Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL, United States.
Department of Chemistry, Chemical Engineering and Materials Science, Biomedical Engineering, University of California, Irvine, Irvine, CA, United States.
Front Immunol. 2020 Sep 25;11:511513. doi: 10.3389/fimmu.2020.511513. eCollection 2020.
Adjuvants are added to vaccines to enhance the immune response and provide increased protection against disease. In the last decade, hundreds of synthetic immune adjuvants have been created, but many induce undesirable levels of proinflammatory cytokines including TNF-α and IL-6. Here we present small molecule NF-κB inhibitors that can be used in combination with an immune adjuvant to both decrease markers associated with poor tolerability and improve the protective response of vaccination. Additionally, we synthesize a library of honokiol derivatives identifying several promising candidates for use in vaccine formulations.
佐剂被添加到疫苗中以增强免疫反应，并提供对疾病的更高保护。在过去的十年中，已经创造了数百种合成免疫佐剂，但许多佐剂会引起包括 TNF-α和 IL-6 在内的促炎细胞因子的不良水平。在这里，我们提出了小分子 NF-κB 抑制剂，可与免疫佐剂联合使用，以降低与耐受性差相关的标志物，并改善疫苗接种的保护反应。此外，我们合成了一系列厚朴酚衍生物库，确定了几种有前途的候选物可用于疫苗制剂。
