Caminha Guilherme Pilla, Pizzichini Emilio, Lubianca Neto José Faibes, Hopkins Claire, Moreira José da Silva, Pizzichini Marcia Margaret Menezes
Department of Internal Medicine, NUPAIVA Research Center, Federal University of Santa Catarina (UFSC), Florianopolis, Brazil.
Post Graduate Program in Pulmonary Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, Brazil.
Clin Otolaryngol. 2018 Dec;43(6):1560-1565. doi: 10.1111/coa.13215. Epub 2018 Sep 19.
OBJECTIVE (S): To estimate the prevalence and associations among rhinosinusitis symptoms, smoking and chronic obstructive pulmonary disease (COPD).
Cross-sectional study.
Population-based.
All adults aged 40 years or more living in the selected households in the city of Florianópolis (Florianópolis, Santa Catarina, Brazil).
Assessment instruments comprised household interviews, anthropometric measurements and spirometry. Rhinosinusitis symptoms were based on the responses to the 22-item Sinonasal Outcome Test (SNOT-22) questionnaire; smoking status was defined by the criteria of the CDC, and the functional diagnosis of COPD was done by spirometry.
The prevalence (n = 1056) of rhinosinusitis symptoms, smoking and COPD was 14.7%, 17.9% and 8.7%, respectively. Multivariate analysis showed that, with the exception of COPD, all other clinical variables (smoking, previous diagnosis of rhinitis, previous diagnosis of gastritis/ulcer/gastroesophageal reflux, and symptoms of depression) remained associated with higher prevalence of rhinosinusitis symptoms.
Rhinosinusitis symptoms were common both in smokers and in patients with COPD. However, only tobacco was significantly associated with rhinosinusitis symptoms and can act as a cofounder in the association between COPD and rhinosinusitis symptoms.
评估鼻窦炎症状、吸烟与慢性阻塞性肺疾病（COPD）之间的患病率及关联。
横断面研究。
基于人群。
居住在弗洛里亚诺波利斯市（巴西圣卡塔琳娜州弗洛里亚诺波利斯）选定家庭中的所有40岁及以上成年人。
评估工具包括家庭访谈、人体测量和肺活量测定。鼻窦炎症状基于对22项鼻鼻窦结局测试（SNOT-22）问卷的回答；吸烟状况根据美国疾病控制与预防中心的标准定义，COPD的功能诊断通过肺活量测定完成。
鼻窦炎症状、吸烟和COPD的患病率（n = 1056）分别为14.7%、17.9%和8.7%。多变量分析表明，除COPD外，所有其他临床变量（吸烟、既往鼻炎诊断、既往胃炎/溃疡/胃食管反流诊断以及抑郁症状）与鼻窦炎症状的较高患病率仍相关。
鼻窦炎症状在吸烟者和COPD患者中均很常见。然而，只有烟草与鼻窦炎症状显著相关，并且可能在COPD与鼻窦炎症状之间的关联中起混杂因素的作用。
