Backer Vibeke, Klein Ditte K, Bodtger Uffe, Romberg Kerstin, Porsbjerg Celeste, Erjefält Jonas S, Kristiansen Karsten, Xu Ruiqi, Silberbrandt Alexander, Frøssing Laurits, Hvidtfeldt Morten, Obling Nicolai, Jarenbäck Linnea, Nasr Abir, Tufvesson Ellen, Mori Michiko, Winther-Jensen Matilde, Karlsson Lisa, Nihlén Ulf, Veje Flintegaard Thomas, Bjermer Leif
Centre for Physical Activity Research, Rigshospitalet, Copenhagen University, Copenhagen, Denmark.
Respiratory Research Unit, Department of Respiratory Medicine, Bispebjerg University Hospital, Copenhagen, Denmark.
Eur Clin Respir J. 2020 Mar 17;7(1):1736934. doi: 10.1080/20018525.2020.1736934. eCollection 2020.
The BREATHE study is a cross-sectional study of real-life patients with asthma and/or COPD in Denmark and Sweden aiming to increase the knowledge across severities and combinations of obstructive airway disease. Patients with suspicion of asthma and/or COPD and healthy controls were invited to participate in the study and had a standard evaluation performed consisting of questionnaires, physical examination, FeNO and lung function, mannitol provocation test, allergy test, and collection of sputum and blood samples. A subgroup of patients and healthy controls had a bronchoscopy performed with a collection of airway samples. The study population consisted of 1403 patients with obstructive airway disease (859 with asthma, 271 with COPD, 126 with concurrent asthma and COPD, 147 with other), and 89 healthy controls (smokers and non-smokers). Of patients with asthma, 54% had moderate-to-severe disease and 46% had mild disease. In patients with COPD, 82% had groups A and B, whereas 18% had groups C and D classified disease. Patients with asthma more frequently had childhood asthma, atopic dermatitis, and allergic rhinitis, compared to patients with COPD, asthma + COPD and Other, whereas FeNO levels were higher in patients with asthma and asthma + COPD compared to COPD and Other (18 ppb and 16 ppb vs 12.5 ppb and 14 ppb, < 0.001). Patients with asthma, asthma + COPD and Other had higher sputum eosinophilia (1.5%, 1.5%, 1.2% vs 0.75%, respectively, < 0.001) but lower sputum neutrophilia (39.3, 43.5%, 40.8% vs 66.8%, < 0.001) compared to patients with COPD. The BREATHE study provides a unique database and biobank with clinical information and samples from 1403 real-life patients with asthma, COPD, and overlap representing different severities of the diseases. This research platform is highly relevant for disease phenotype- and biomarker studies aiming to describe a broad spectrum of obstructive airway diseases.
BREATHE研究是一项针对丹麦和瑞典现实生活中哮喘和/或慢性阻塞性肺疾病（COPD）患者的横断面研究，旨在增进对阻塞性气道疾病不同严重程度及合并情况的了解。疑似哮喘和/或COPD的患者以及健康对照被邀请参与该研究，并接受了包括问卷调查、体格检查、呼出一氧化氮（FeNO）检测、肺功能检测、甘露醇激发试验、过敏试验以及痰液和血液样本采集在内的标准评估。部分患者和健康对照亚组接受了支气管镜检查并采集气道样本。研究人群包括1403例阻塞性气道疾病患者（859例哮喘患者、271例COPD患者、126例哮喘合并COPD患者、147例其他疾病患者）以及89例健康对照（吸烟者和非吸烟者）。哮喘患者中，54%患有中度至重度疾病，46%患有轻度疾病。在COPD患者中，82%属于A组和B组，而18%属于C组和D组分类疾病。与COPD患者、哮喘合并COPD患者及其他疾病患者相比，哮喘患者更常患有儿童哮喘、特应性皮炎和过敏性鼻炎，而哮喘患者和哮喘合并COPD患者的FeNO水平高于COPD患者及其他疾病患者（分别为18 ppb和16 ppb，对比12.5 ppb和14 ppb，P<0.001）。与COPD患者相比，哮喘患者、哮喘合并COPD患者及其他疾病患者的痰液嗜酸性粒细胞增多（分别为1.5%、1.5%、1.2%对比0.75%，P<0.001），但痰液中性粒细胞减少（分别为39.3%、43.5%、40.8%对比66.8%，P<0.001）。BREATHE研究提供了一个独特的数据库和生物样本库，包含来自1403例现实生活中哮喘、COPD及重叠疾病患者的临床信息和样本，代表了疾病的不同严重程度。该研究平台对于旨在描述广泛阻塞性气道疾病的疾病表型和生物标志物研究具有高度相关性。
