Department of Neurology, Jinshan Hospital, Fudan University, Shanghai, China.
Department of Neurology, Huashan Hospital North, Fudan University, Shanghai, China.
CNS Neurol Disord Drug Targets. 2018;17(10):728-735. doi: 10.2174/1871527317666180828121820.
BACKGROUND & OBJECTIVE: Epilepsy is a common and serious chronic neurological disorder that is mainly treated with antiepileptic drugs. Although current antiepileptic drugs used in clinical practice have advanced to the third generation, approximately one-third of patients are refractory to these treatments. More efficacious treatments for refractory epilepsy are therefore needed. A better understanding of the mechanism underlying refractory epilepsy is likely to facilitate the development of a more effective therapy. The abnormal expression and/or dysfunction of efflux transporters, particularly ABC transporters, might contribute to certain cases of refractory epilepsy. Inflammation in the brain has recently been shown to regulate the expression and/or function of ABC transporters in the cerebral vascular endothelial cells and glia of the blood-brain barrier by activating intracellular signalling pathways.
Therefore, in this review, we will briefly summarize recent research advances regarding the possible role of neuroinflammation in regulating ABC transporter expression in epilepsy.
癫痫是一种常见且严重的慢性神经系统疾病，主要采用抗癫痫药物进行治疗。尽管目前临床实践中使用的抗癫痫药物已发展到第三代，但仍有约三分之一的患者对此类治疗无效。因此，需要寻找更有效的治疗难治性癫痫的方法。更好地了解难治性癫痫的发病机制可能有助于开发更有效的治疗方法。外排转运体（尤其是 ABC 转运体）的异常表达和/或功能障碍可能与某些难治性癫痫病例有关。最近的研究表明，通过激活细胞内信号通路，脑内炎症可调节血脑屏障的脑血管内皮细胞和神经胶质细胞中 ABC 转运体的表达和/或功能。
因此，在这篇综述中，我们将简要总结有关神经炎症在调节癫痫中 ABC 转运体表达方面的最新研究进展。
