School of Materials Science and Engineering, Tianjin Key Laboratory of Composite and Functional Materials, Tianjin University, Tianjin 300350, China.
Chem Commun (Camb). 2018 Sep 18;54(75):10540-10553. doi: 10.1039/c8cc04614j.
It has been fifty-four years since the N-acryloyl glycinamide (NAGA) monomer and its polymer (PNAGA) were first reported (in 1964). Over the past decades, PNAGA aqueous solution systems within a broad concentration range have been prepared and significantly distinct performances have been observed. This feature article is aimed toward introducing the representative properties (aggregation, UCST-type phase separation, the thermoreversible sol ⇔ gel transition behaviors and the high mechanical properties) of PNAGA aqueous systems with three concentration regions (low, medium and high concentration). In particular, the fabrication of dual-amide hydrogen bonding reinforced high-strength supramolecular polymer hydrogels and the relevant biomedical applications are highlighted. The potential challenges, as well as the future prospects of the PNAGAs, are also indicated.
自 1964 年首次报道 N-丙烯酰基甘氨酸酰胺（NAGA）单体及其聚合物（PNAGA）以来，已经过去了五十四年。在过去的几十年中，已经制备了在较宽浓度范围内的 PNAGA 水溶液体系，并观察到了显著不同的性能。本文旨在介绍 PNAGA 水溶液体系在三个浓度区域（低、中、高浓度）下的代表性性质（聚集、UCST 型相分离、热可逆溶胶-凝胶转变行为和高机械性能）。特别是，强调了双酰胺氢键增强的高强度超分子聚合物水凝胶的制备及其相关的生物医学应用。还指出了 PNAGA 的潜在挑战和未来前景。
